sra Antibody

Code CSB-PA156329XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) sra Polyclonal antibody
Uniprot No.
Target Names
sra
Alternative Names
sra antibody; nla antibody; CG6072 antibody; Protein sarah antibody; Protein nebula antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) sra protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Required for elongation of meiosis I spindle. Critical for ovulation, meiotic progression in oocytes and female courtship behavior, including their postmating changes. Regulates female meiosis by controlling calcineurin activity in the germline. Has a role in calcium signaling during egg activation; bcd mRNA polyadenylation and translation in the oocyte.
Gene References into Functions
  1. Data suggest that sra negatively regulates calcineurin by cell-autonomously titrating calcineurin-dependent stabilization of PER and TIM proteins, thereby sustaining high-amplitude behavioral rhythms in Drosophila. PMID: 29724861
  2. sra overexpression augments Abeta42 cytotoxicity in Drosophila. PMID: 26659252
  3. Our data further suggest that upregulation of Nebula/DSCR1 is neuroprotective in the presence of APP upregulation and provides evidence for calcineurin inhibition as a novel target for therapeutic intervention of Alzheimer's disease . PMID: 24086147
  4. Calcineurin and its regulation by Sra are required for normal sleep in Drosophila PMID: 21900555
  5. we describe a novel role of sra in Drosophila male courtship behavior PMID: 20736865
  6. both nebula loss-of-function and overexpression mutants exhibit severe learning defects that are attributed by biochemical perturbations rather than maldevelopment of the brain PMID: 14668437

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Protein Families
RCAN family
Tissue Specificity
Expressed in central nervous system of the third instar larvae, with a relatively intense signal in the brain and weak signals in the ventral ganglion. Relatively low, but ubiquitous expression level is observed in leg and wing imaginal disks, no signal i
Database Links

KEGG: dme:Dmel_CG6072

STRING: 7227.FBpp0082709

UniGene: Dm.1655

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