Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans src-1 Polyclonal antibody

Uniprot No.

G5EE56

Target Names

src-1

Alternative Names

src-1 antibody; Y92H12A.1 antibody; Tyrosine protein-kinase src-1 antibody; EC 2.7.10.2 antibody; SRC oncogene related protein 1 antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans src-1 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Non-receptor tyrosine-protein kinase which plays a role in endoderm development by controlling spindle orientation in EMS blastomere, probably downstream of receptor mes-1. Also involved in embryonic body morphogenesis, especially in the formation of the pharynx and the intestine. May be dispensable for pharyngeal muscle organization in the adult. Probably phosphorylates netrin receptor unc-5, to regulate distal tip cell (DTC) migration during gonad development and in axon repulsion. Plays a role in the migration of the QR neuroblast, a precursor of the AVM neuron, and in the migration of the axon cone of AVM, ALM, CAN and PVM neurons. May act downstream of migratory protein mig-13 to control AVM neuron migration. Probably downstream of integrin ina-1/pat-3, plays a role in the clearance of apoptotic cells during mid-embryogenesis.

Gene References into Functions

Data indicate that a positive correlation between SRC-1 and the on-rate of PAR-2 is the essential mechanism underlying polarity reversal. PMID: 27086039
Data suggest that MIG-13 controls anteroposterior cell migration by interacting with UNC-71 and SRC-1 in C. elegans. PMID: 22293500
identify an essential role of the nonreceptor tyrosine kinase SRC-1 in INA-1-mediated cell corpse removal PMID: 20226672
These results suggest that SRC-1 and KIN-22 play distinct roles under the control of CSK-1. PMID: 12527374
SRC-1 is required for UNC-5-induced axon repulsion and gonad migration signaling pathways and in which localizing SRC-1 activity to UNC-5 is crucial for proper signal transduction in response to unc-6/netrin. PMID: 16024786
SRC-1 functions in responding to various extracellular guidance cues that direct the cell migration via disparate signaling pathways in different cell types. PMID: 16251208
Src and Wnt signaling regulate dynactin accumulation to the P2-EMS cell border in C. elegans embryos PMID: 18187449

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Subcellular Location

Cell membrane; Lipid-anchor; Cytoplasmic side. Cell projection, phagocytic cup.

Protein Families

Protein kinase superfamily, Tyr protein kinase family, SRC subfamily

Tissue Specificity

Expressed in some neurons (ASE, ADF, AVA, AUA, RMDV and BAG) in the head region, anchor cell, vulva, cells around anus, body wall muscle, pharyngeal muscles in procorpus and metacorpus. Expressed in gonadal distal tip cells.

Database Links

KEGG: cel:CELE_Y92H12A.1

STRING: 6239.Y92H12A.1

UniGene: Cel.17902

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src-1 Antibody

Product Details

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Target Background