SREK1 Antibody

Code CSB-PA837871ZA01HU
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SREK1 Polyclonal antibody
Uniprot No.
Target Names
SREK1
Alternative Names
SREK1 antibody; SFRS12 antibody; SRRP86Splicing regulatory glutamine/lysine-rich protein 1 antibody; Serine/arginine-rich-splicing regulatory protein 86 antibody; SRrp86 antibody; Splicing factor antibody; arginine/serine-rich 12 antibody; Splicing regulatory protein 508 antibody; SRrp508 antibody
Raised in
Rabbit
Species Reactivity
Homo sapiens
Immunogen
Recombinant Homo sapiens SREK1 protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (12-14 weeks)

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Target Background

Function
Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3.
Gene References into Functions
  1. From among the 500 splicing events exhibiting altered splicing under these conditions, the splicing of c-Jun and IkappaBbeta were validated as being regulated by SRrp86 resulting in altered regulation of their downstream targets. PMID: 20400856
  2. SRrp86 can activate SRp20 and repress SC35 in a dose-dependent manner both in vitro and in vivo PMID: 11991645
  3. the unique glutamic acid-lysine domain of SRrp86 plays a modulatory role controlling serine-arginine domain function PMID: 12183448
  4. p18SRP is a lysine-rich zinc finger domain-containing protein that interacts with the serine-arginine-rich splicing regulatory protein SRrp86; it is downregulated in brain of Alzheimer disease patients. PMID: 15456940
Subcellular Location
Nucleus.
Protein Families
Splicing factor SR family
Database Links

HGNC: 17882

OMIM: 609268

KEGG: hsa:140890

STRING: 9606.ENSP00000334538

UniGene: Hs.49367

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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