srp Antibody

Code CSB-PA345974XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) srp Polyclonal antibody
Uniprot No.
Target Names
srp
Alternative Names
srp antibody; ABF antibody; CG3992Box A-binding factor antibody; ABF antibody; GATA-binding factor B antibody; Protein serpent antibody; Transcription factor GATA-B antibody; dGATA-B antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) srp protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
May function as a transcriptional activator protein and may play a key role in the organogenesis of the fat body. Binds a sequence element (5'-[TA]GATAA-3') found in the larval promoters of all known alcohol dehydrogenase (ADH) genes. Acts as a homeotic gene downstream of the terminal gap gene HKB to promote morphogenesis and differentiation of anterior and posterior midgut.
Gene References into Functions
  1. several genes work in a combined fashion to restrain early srp expression to the head mesoderm in order to prevent expansion of the hemocyte primordium PMID: 24360907
  2. A second 20E-mediated mechanism, which robustly affects only a subset of AMP genes, is uniquely controlled by BR-C, SRP and PNR. PMID: 23652443
  3. Serpent regulates eater expression by binding to GATA sites. PMID: 21809435
  4. functions of SrpC and SrpNC during embryonic haematopoiesis PMID: 12374748
  5. plays a pivotal role during crystal cell lineage commitment, acting as an activator or repressor depending on the availability of specific transcriptional coregulators PMID: 14504400
  6. In Drosophila, the GATA factor Serpent (Srp) is required in blood cell progenitors for the formation of the two populations of blood cells PMID: 14657024
  7. Directly regulates the activity of both enhancers of "u-shaped" protein. PMID: 16730345
  8. We find that both migrating prohemocytes and posterior mesodermal cells, before their integration into the Malpighian tubule primordia, simultaneously express the hibris reporter and Serpent PMID: 17362344

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Subcellular Location
Nucleus.
Database Links

KEGG: dme:Dmel_CG3992

STRING: 7227.FBpp0082669

UniGene: Dm.1934

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