ssh Antibody

Code CSB-PA740638XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) ssh Polyclonal antibody
Uniprot No.
Target Names
ssh
Alternative Names
ssh antibody; CG6238 antibody; Protein phosphatase Slingshot antibody; EC 3.1.3.16 antibody; EC 3.1.3.48 antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) ssh protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor tsr/cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Required for axon growth.
Gene References into Functions
  1. In mature neurons SSH may function as a stabilization factor for filamentous actin instead of promoting actin depolymerization. PMID: 24587072
  2. we found that Capt(Capulet) and Ssh(Slingshot), but not Tsr, share overlapping functions during eye morphogenesis PMID: 22545588
  3. Ssh acts in the developing eye to limit actin polymerization in the assembling ommatidia, but not in the morphogenetic furrow. PMID: 16169194
Subcellular Location
Cytoplasm, cytoskeleton.
Protein Families
Protein-tyrosine phosphatase family
Database Links

KEGG: dme:Dmel_CG6238

STRING: 7227.FBpp0084175

UniGene: Dm.1518

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