Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) Ssrp Polyclonal antibody

Uniprot No.

Q05344

Target Names

Ssrp

Alternative Names

Ssrp antibody; CF5 antibody; SSRP1 antibody; CG4817 antibody; FACT complex subunit Ssrp1 antibody; Chorion-factor 5 antibody; Facilitates chromatin transcription complex subunit Ssrp1 antibody; Recombination signal sequence recognition protein antibody; Single-strand recognition protein antibody; dSSRP1 antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) Ssrp protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. Binds specifically to single-stranded DNA and RNA with highest affinity for nucleotides G and U. The FACT complex is required for expression of Hox genes.

Gene References into Functions

alternatively spliced isoforms control self-renewal in neuroblast lineages PMID: 21549331
results show that FACT, a heterodimer of dSPT16 and dSSRP1, associates with GAGA factor through its dSSRP1 subunit & facilitates chromatin remodeling; interactions between GAGA factor and spt16 implicate the GAGA factor-FACT complex in Hox gene expression PMID: 12815073
Results report the solution structure of the HMG-box domain in Drosophila SSRP1. PMID: 16041486
Study shows that the GAGA factor-FACT complex and its binding site just downstream from the white gene are crucial for position effect variegation. PMID: 17344416
rapid chromatin transactions during early embryogenesis through the dephosphorylation of some sites in the maternally transmitted dSSRP1 PMID: 19605348

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Subcellular Location

Nucleus. Chromosome. Nucleus, nucleolus.

Protein Families

SSRP1 family

Tissue Specificity

Expressed at highest levels in nurse cells of the ovary.

Database Links

KEGG: dme:Dmel_CG4817

STRING: 7227.FBpp0072151

UniGene: Dm.3383

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Ssrp Antibody

Product Details

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Target Background