ste11 Antibody

Code CSB-PA334159XA01SXV
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Product Details

Full Product Name
Rabbit anti-Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) ste11 Polyclonal antibody
Uniprot No.
Target Names
ste11
Alternative Names
ste11 antibody; stex antibody; SPBC32C12.02 antibody; Transcription factor ste11 antibody
Raised in
Rabbit
Species Reactivity
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Immunogen
Recombinant Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) ste11 protein
Immunogen Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Key transcription factor for sexual development. Activates the transcription of the matp, matm, mei2, mfm, ste6 and rgs1 genes. Binds specifically to a DNA fragment carrying a 10-base motif 5'-TTCTTTGTTY-3'.
Gene References into Functions
  1. REVIEW: Regulation of entry into gametogenesis by Ste11 PMID: 24256273
  2. Msa2 may regulate the translation of Ste11, be a component of stress granules that form in response to glucose starvation, and regulate the sexual differentiation of S. pombe. PMID: 21409593
  3. Study conclude that both the PKA and the TOR pathways inhibit Ste11 nuclear accumulation to repress Ste11-dependent gene expression. PMID: 20634885
  4. Ste11 transcription factor becomes constitutively expressed in cells with induced mitogen-activated protein kinase kinase kinase (MAP3K) Byr2. PMID: 15713656
  5. In fission yeast, induction of the transcription factor Ste11 triggers sexual differentiation. PMID: 17289922
  6. Data show that the SAGA subunit Spt8 is required for the induction of ste11(+) upon nutrient starvation. and SAGA is physically associated with the ste11(+) promoter independent of nutrient levels. PMID: 19056896

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Subcellular Location
Nucleus. Cytoplasm. Note=Accumulates in the nucleus under conditions of nitrogen starvation and in the presence of mating pheromones.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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