STE5 Antibody

1. defining regions of Ste5 that mediate nuclear export PMID: 26824509
2. Structural determinants of the specificity of a membrane binding domain of the scaffold protein Ste5 of budding yeast: implications in signaling by the scaffold protein in MAPK pathway. PMID: 22285780
3. findings show that the scaffold protein Ste5, which organizes the yeast mating mitogen-activated protein kinase pathway, does not use sequestration to prevent misactivation of the mating response; Ste5 appears to use a conformation mechanism PMID: 22878499
4. The signaling proteins Ste5 and Ste20 have recognition sequences, or "docking" sites, for G1/S (interphase) cyclins. These docking sites bind preferentially to the cyclin Cln2, and strongly enhance Cln2-driven in vivo substrate phosphorylation. PMID: 21945277
5. a switch-like dissociation of Fus3 from Ste5 that is necessary to generate the switch-like mating response PMID: 20400943
6. KSS1 is activated by Ste5. PMID: 15192700
7. Ste5p scaffold feedback phosphorylation is controlled by an associated MAPK cascade PMID: 15322134
8. Ste5 scaffold has a more active role in the yeast mating pathway; a fragment of Ste5 allosterically activated autophosphorylation of Fus3 PMID: 16424299
9. Ste5 contains a pleckstrin-homology (PH) domain (residues 388-518) that is essential for its membrane recruitment and function. PMID: 16847350
10. Cln/CDK disrupts Ste5 membrane localization by phosphorylating a cluster of sites that flank a small, basic, membrane-binding motif in Ste5; effective inhibition requires multiple phosphorylation sites and a substantial accumulation of negative charge PMID: 17289571
11. Fus3 activity requires the scaffold protein Ste5; when binding to Ste5 is abrogated, Fus3 behaves like Kss1, and the cells no longer respond to a gradient or mate efficiently with distant partners PMID: 18538663
12. study found that the subcellular localization of Ste5 and cell cycle progression have dramatic effects in controlling the stability of Ste5 PMID: 19001089
13. The dual requirement for both Ste7 and this Ste5 domain in Fus3 activation explains why Fus3 is selectively activated by the mating pathway and not by other pathways that also utilize Ste7. PMID: 19303851

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KEGG: sce:YDR103W

STRING: 4932.YDR103W