unc-64 Antibody

Code CSB-PA522693XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans unc-64 Polyclonal antibody
Uniprot No.
Target Names
unc-64
Alternative Names
unc-64 antibody; F56A8.7 antibody; Syntaxin-1A homolog antibody; Uncoordinated protein 64 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans unc-64 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Plays a critical role in several secretory processes, including cuticle secretion and neurotransmitter release, and probably assists in neuronal membrane maturation or the final stages of neuronal differentiation. Essential for embryonic viability and development. Has a role in dauer formation and adult life span. Required for locomotion. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt.
Gene References into Functions
  1. The plasma membrane-associated SNAREs syntaxin/unc-64 and SNAP-25/ric-4 function in parallel in regulating fat storage in C. elegans and regulate fat storage. PMID: 20332815
  2. The UNC-13/Syntaxin interaction is required for nerve-evoked vesicle fusion and synaptic transmission. PMID: 16271476
Subcellular Location
Membrane; Single-pass type IV membrane protein.
Protein Families
Syntaxin family
Tissue Specificity
Expressed throughout the head ganglion, nerve ring, ventral cord, dorsal cord, intestine, vulva and spermatheca.
Database Links

KEGG: cel:CELE_F56A8.7

STRING: 6239.F56A8.7b

UniGene: Cel.18377

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