Stxbp3 Antibody

1. Investigated the use of Escherichia coli as an expression host for Munc18c. Three N-terminal His-tagged constructs were engineered, two with a tobacco etch virus (TEV) or thrombin protease cleavage site to enable removal of the fusion tag. PMID: 24391775
2. PTP1B is the first known tyrosine phosphatase for Munc18c and a regulator of its phosphorylation and function in adipocytes. PMID: 23937695
3. Ectopic expression of syntaxin3 affects behaviors of B16 melanoma by controlling actin dynamics. PMID: 23546178
4. The Using 3T3-L1 adipocytes subjected to small interfering ribonucleic acid reduction of Munc18c as a model of impaired insulin-stimulated GLUT4 vesicle exocytosis. PMID: 21444687
5. our data suggest that the mechanism by which glucosamine inhibits insulin-stimulated GLUT4 translocation involves modification of Munc18c. PMID: 12527361
6. balance, more than absolute abundance, of Munc18c and Syn4 proteins directly affects whole-body glucose homeostasis through alterations in insulin secretion and insulin action. PMID: 12882905
7. To define the molecular machinery required for platelet exocytosis, platelets from Munc18c heterozygous knockout mice were analyzed. These platelets show a decrease in Munc18c but no apparent reduction in other secretory machinery components PMID: 15467915
8. Glucose intolerance and insulin secretion in knockout mice heterozygous for Munc18c are reported. PMID: 15734838
9. Munc18c(L) gene is closely related to syntaxin-binding protein, Munc18c.It comprises 2 exons separated by a 600bp intron with non-consensus donor & acceptor sites.Exons 1 & 2 of Munc18c(L) overlap with exons 1 through half of 9 of Munc18c gene. PMID: 16036223
10. novel and conserved mechanism for the dissociation of Munc18c-Syntaxin 4 complexes in a stimulus-dependent manner to facilitate the increase in Syntaxin 4-VAMP2 association and to promote vesicle/granule fusion PMID: 16638745
11. support a sequential two-state model for SM/soluble NSF attachment protein receptors binding involving an initial interaction via the Syntaxins N-peptide PMID: 17517664
12. We conclude, therefore, that Munc18c is not rate-limiting for cardiac substrate uptake, neither under basal conditions nor when maximally stimulated metabolically. PMID: 19009238
13. Essential positive role for Munc18c in second-phase glucose-stimulated insulin secretion. PMID: 19188424

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KEGG: mmu:20912

STRING: 10090.ENSMUSP00000099681

UniGene: Mm.316894