SUA5 Antibody

Code CSB-PA327147XA01SVG
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Product Details

Full Product Name
Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SUA5 Polyclonal antibody
Uniprot No.
Target Names
SUA5
Alternative Names
SUA5 antibody; YGL169W antibody; G1660 antibody; Threonylcarbamoyl-AMP synthase antibody; TC-AMP synthase antibody; EC 2.7.7.87 antibody; L-threonylcarbamoyladenylate synthase antibody; Suppressor of upstream AUG protein 5 antibody; t(6)A37 threonylcarbamoyladenosine biosynthesis protein SUA5 antibody; tRNA threonylcarbamoyladenosine biosynthesis protein SUA5 antibody
Raised in
Rabbit
Species Reactivity
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Immunogen
Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SUA5 protein
Immunogen Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Likely catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Required for normal translation, by ensuring translation fidelity at the level of codon recognition, appropriate translation initiation selection and maintenance of reading frame. Also involved in telomere replication. Binds to single-stranded telomeric (ssTG) DNA and positively regulates telomere length.
Gene References into Functions
  1. Sua5p is involved in the telomeric DNA recombination in telomerase-negative cells. PMID: 20309016
  2. A critical role for Sua5 and the t(6)A(37) modification in translational fidelity is revealed. PMID: 19884342
  3. Deletion of SUA5 gene led to the loss of threonylcarbamoyladenosine. PMID: 19287007
  4. Thus, Sua5p represents a novel ssTG DNA-binding protein and positively regulates the telomere length in vivo. PMID: 19369944
Subcellular Location
Cytoplasm. Nucleus. Chromosome, telomere.
Protein Families
SUA5 family
Database Links

KEGG: sce:YGL169W

STRING: 4932.YGL169W

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