SUB1 Antibody

1. Evolutionarily conserved role for Sub1 and PC4 in the maintenance of yeast and human genome stability has been summarized. (Review) PMID: 28567479
2. Yeast Sub1 and human PC4 are G-quadruplex binding proteins that suppress genome instability at co-transcriptionally formed G4 DNA. PMID: 28369605
3. demonstrate that purified Sub1 protein can protect DNA from oxidative damage in vitro, using the metal ion catalyzed oxidation assay PMID: 26708217
4. This hypothesis was reinforced by the finding that inactivation of Sub1 transcription initiation factor, which is found predominantly in the regions of transcription initiation, leads to further increase in mutagenesis in the beginning of the genes. PMID: 25941824
5. results suggest that SUB1 acts as a negative regulator of sporulation. PMID: 26147804
6. Sub1, and its human homolog PC4, bind preferentially to G-quadruplexes PMID: 25813861
7. Differential requirement for SUB1 in chromosomal and plasmid double-strand DNA break repair. PMID: 23554872
8. Propose that Sub1 and RPA interact with the nontemplate strand of RNA polymerase II complexes during initiation and elongation, respectively. PMID: 22055186
9. multiple roles for Sub1 in the regulation of RNA polymerase II C-terminal domain phosphorylation throughout the transcription cycle PMID: 20823273
10. Sub1 influences and/or is sensitive to the phosphorylation status of elongating RNAP II. PMID: 15692559
11. the transcriptional co-activator Sub1 also has a role in transcriptional repression during transcription initiation in vivo. PMID: 18823333
12. during osmotic shock, Sub1 facilitates osmoresponse gene transcription by enhancing preinitiation complex formation PMID: 19204085
13. Data showed that Sub1 was required for optimal Pol III gene transcription in exponentially growing cells. PMID: 19706510

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KEGG: sce:YMR039C

STRING: 4932.YMR039C