Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) Su(H) Polyclonal antibody

Uniprot No.

P28159

Target Names

Su(H)

Alternative Names

Su(H) antibody; dRBP-JK antibody; CG3497 antibody; Suppressor of hairless protein antibody; J kappa-recombination signal-binding protein antibody; RBP-J kappa antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) Su(H) protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Binds directly the 5'-GTGRGAR-3' DNA consensus sequence, which is present in the regulatory region of several genes. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some Notch protein, it acts as a transcriptional activator that activates transcription of Notch target genes. Required for transcription of Sim. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Required for neurogenesis in imaginal disks. In the larval brain, might play a role as a transducer of Notch signaling during type II neuroblast development. Also functions independently of the Notch pathway, in the development of the bristle sensory organ precursor cell.

Gene References into Functions

complex genetic interactions of novel alleles deficient in co-repressor binding PMID: 29509808
Structural models show that the Hairless-Su(H) repressor complexes from Daphnia and Drosophila are almost indistinguishable from one another. Amino acid residues in direct contact within the Hairless-Su(H) complex are at absolutely identical positions in the two homologues. PMID: 28861687
Su(H) protein levels depend on the interactions with H as well as with Notch. PMID: 28475577
X-ray structure of the Su(H)-Hairless complex bound to DNA. PMID: 27404588
The role of Su(H) in conferring chromatin characteristics at Notch-regulated enhancers PMID: 26069324
the molecular cross talk at the level of Suppressor of Hairless [Su(H)], is reported. PMID: 25452105
human RITA, binding to Drosophila Su(H) and tubulin, cannot influence the Notch signalling pathway in the fly PMID: 25588307
Su(H) repression acts as a counterbalance to Dorsal- and Zelda-mediated activation. PMID: 25313963
This study demonistrated that transcriptional activity of Su(H) in Notch signaling in the mushroom bodies is critical for the formation of long-term memory. PMID: 19863271
the C-terminal domain of Su(H) is necessary and sufficient for forming a high-affinity complex with Hairless PMID: 21737682
Su(H)-H complexes can bind to DNA with high efficiency in vitro. Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless. PMID: 12154126
Loss of Su(H) function leads to an arrest of sensory organ precursors development PMID: 12642500
the accumulation of Notch (N) in the late-endosome was required for the deltex -mediated Su(H)-independent N signaling PMID: 15496440
crucial roles for the adaptor protein Hairless in conferring repressive activity on Su(H) in the Drosophila sensory organ precursor. PMID: 15975935
acts on identified regulatoru seq pf roughest gene PMID: 16096801
Su(H) acts as a transcriptional repressor in the absence of a Notch signal and as a transcriptional activator in its presence in several developmental contexts. PMID: 16397895

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Subcellular Location

Nucleus. Cytoplasm.

Protein Families

Su(H) family

Database Links

KEGG: dme:Dmel_CG3497

STRING: 7227.FBpp0080261

UniGene: Dm.2288

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Su(H) Antibody

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