su(Hw) Antibody

1. Study highlights that Su(Hw) has a major developmental function as a transcriptional repressor, with the effect of its loss dependent upon the cell-specific factors. PMID: 29739818
2. the role of the Su(Hw) protein in Drosophila oogenesis as a transcription repressor PMID: 29779102
3. Role of Su(Hw) zinc finger 10 and interaction with CP190 and Mod(mdg4) proteins in recruiting the Su(Hw) complex to chromatin sites in Drosophila PMID: 29474480
4. Su(Hw) genomic sites separate into sequence subclasses comprised of combinations of modules, with subclasses enriched for different chromatin features. PMID: 28158673
5. Study of the role of Mod(mdg4)-67.2 and Su(Hw) proteins in the interaction between Su(Hw)-dependent insulator complexes and identifying the specific domains of the Su(Hw) protein required for insulation or mutual neutralization of insulators; demonstrated that the Su(Hw) protein zinc finger domain is involved in forming a functional insulator complex and cannot be replaced with the DNA-binding domain of the GAL4 protein PMID: 27599504
6. It was demonstrated that the interaction of Su(Hw) and Mod(mdg4)-67.2 insulator proteins with the terminator regions of the selected genes was dependent on the Su(Hw) factor. PMID: 26845853
7. loss of su(Hw) affects expression of many oogenesis related genes and down-regulates Src64B, resulting in ring canal defects potentially contributing to obstruction of molecular flow and an eventual failure of egg chamber organization. PMID: 25882370
8. The insulator protein Suppressor of Hairy-wing is an essential transcriptional repressor in the Drosophila ovary. PMID: 23884443
9. Completion of the first genome-wide analysis of Su(Hw)-binding sites in the ovary, shows that tissue-specific binding is not responsible for the restricted developmental requirements for Su(Hw). PMID: 22406832
10. Accumulation of these proteins is distinct from Su(Hw), with Mod67.2 and CP190 showing uniform expression in all cells during early stages of oogenesis that diminishes in later stages PMID: 21651900
11. Studies identify SU(HW) as a fine-tuner of genome - NL interactions. PMID: 21124834
12. Data show that gypsy-Su(Hw) system enhanced expression levels, but did not alter the specificity of promoter activities. PMID: 20516496
13. most Su(Hw) binding sites are largely associated with compacted chromatin and that Su (Hw) binding sites associated with open chromatin in interbands may have properties different from Su(Hw) binding sites found in condensed chromatin. PMID: 20033198
14. Suppressor of Hairy wing and Modifier of MDG4 are involved in the transcriptional regulation of Achaete-scute PMID: 12783795
15. Su(Hw) insulator's actions in the absence of the Mod(mdg4) protein PMID: 12856417
16. 1A-2 is an endogenous Su(Hw) insulator that separates regulatory domains within the Drosophila genome PMID: 14597701
17. The Su(Hw) insulator can modulate interactions between transposase complexes bound to the ends of the P transposon in germ cells. PMID: 15280241
18. Su(Hw) insulator can stimulate transcription of a weakened yellow promoter over a distance. PMID: 15520254
19. Analysis of interaction between the insulator Su(Hw) and the regulatory elements of the Abdominal-B gene of Drosophila melanogaster. PMID: 15584504
20. Analysis of the effect of the Su(Hw) insulator on the expression of the miniwhite gene in Drosophila melanogaster. PMID: 15584507
21. analysis of the role of the acid domain located at the C-terminus of the Su(Hw) protein PMID: 15846971
22. Su(Hw) regulates an evolutionarily conserved silencer from the mouse H19 imprinting control region. PMID: 16117632
23. Polycomb group response elements (PRE) silence neighboring genes, but silencing can be blocked by one copy of the Su(Hw) insulator element. PRE-mediated silencing can bypass two Su(Hw) insulators to repress a downstream reporter gene. PMID: 16824958
24. These studies provide the first direct evidence that the Su(Hw) protein contributes to the regulation of gene expression in the Drosophila genome through the establishment of endogenous insulators. PMID: 16880510
25. E(y)2/Sus1, is recruited to the Su(Hw) insulators via binding to the zinc-finger domain of Su(Hw). PMID: 17643381
26. A mutant Mod(mdg4) protein devoid of the Q-rich domain supports the function of Su(Hw)-dependent insulators and efficiently binds to correct insulator sites on the chromosome, but does not form or enter the Su(Hw)-marked nuclear speckles. PMID: 18369369
27. These studies extend the understanding of the properties of Su(Hw) and the endogenous genomic regions to which this protein localizes. PMID: 18562648
28. transcription factor E(y)2/Sus1 interacted with the Su(Hw) zinc-finger domain and was present in the protein complex, associated with the Su(Hw)-dependent insulators. PMID: 19382683

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KEGG: dme:Dmel_CG8573

STRING: 7227.FBpp0082404

UniGene: Dm.2430