sun-1 Antibody

Code CSB-PA635315XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans sun-1 Polyclonal antibody
Uniprot No.
Target Names
sun-1
Alternative Names
sun-1; mtf-1; F57B1.2; Sun domain-containing protein 1
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans sun-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Involved in centrosome attachment to the nucleus. Required for zyg-12 localization to the nuclear envelope. Together with pot-1, it is required to anchor telomeres to the nuclear envelope in embryos.
Gene References into Functions
  1. Coiled-coil domains of SUN-1 are required for oligomerization and retention of the protein in the nuclear envelope, especially at later stages of female gametogenesis. PMID: 27098914
  2. POT-1 has a role in anchoring telomeres through SUN-1 at the nuclear periphery. PMID: 24297748
  3. This suggests that SUN-1 phosphorylation is critical to delaying meiosis in response to perturbed synapsis. SUN-1 may be an integral part of a checkpoint system to monitor establishment of the obligate crossover PMID: 23505384
  4. The dynamics of matefin/SUN-1 aggregates remained unchanged throughout leptonene/zygotene, despite the progression of pairing. PMID: 21124819
  5. [REVIEW]functions of these KASH/SUN protein pairs across spatial and temporal C. elegans development PMID: 20108325
  6. Data show that ZYG-12 is immobile at the outer nuclear membrane and that SUN-1 is sufficient to localize ZYG-12 in cells. PMID: 19759181
  7. Data suggest that the properties of the nuclear envelope are altered during the time window when homologs are sorted and Matefin/SUN-1 aggregates form, thereby controling the movement, homologous pairing and interhomolog recombination of chromosomes. PMID: 19913286

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Subcellular Location
Nucleus membrane; Single-pass membrane protein. Nucleus envelope.
Database Links

KEGG: cel:CELE_F57B1.2

STRING: 6239.F57B1.2

UniGene: Cel.7684

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