Product Details

Full Product Name

Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) SUVH2 Polyclonal antibody

Uniprot No.

O22781

Target Names

SUVH2

Alternative Names

SUVH2 antibody; SDG3 antibody; SET3 antibody; At2g33290 antibody; F4P9.6 antibody; Histone-lysine N-methyltransferase family member SUVH2 antibody; Cytosine-HMTase 2 antibody; H3-K27-HMTase 2 antibody; H4-K20-HMTase 2 antibody; Histone H3-K9 methyltransferase 2 antibody; H3-K9-HMTase 2 antibody; Protein SET DOMAIN GROUP 3 antibody; Suppressor of variegation 3-9 homolog protein 2 antibody; Su(var)3-9 homolog protein 2 antibody

Raised in

Rabbit

Species Reactivity

Arabidopsis thaliana

Immunogen

Recombinant Arabidopsis thaliana SUVH2 protein

Immunogen Species

Arabidopsis thaliana (Mouse-ear cress)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

Histone methyltransferase family member that plays a central role in gene silencing. Together with MORC6 and SUVH9, regulates the silencing of some transposable elements (TEs). According to PubMed:15775980, it is required for normal methylation of 'Lys-9' and 'Lys-27' of histone H3, 'Lys-20' of H4, and cytosine, but PubMed:19043555 see no significant effect on histone methylation when the gene is mutated. According to PubMed:19043555, the protein does not bind S-adenosyl-L-methionine and lacks methyltransferase activity. Instead, it may function downstream of DRM2 in RNA-directed DNA methylation, binding to methylated DNA and recruiting DNA-directed RNA polymerase V to chromatin.

Gene References into Functions

Study propose that SUVH2 and SUVH9 bind to the methylated DNA and facilitate the recruitment of a chromatin-remodeling complex to the target loci in association with MORC proteins. PMID: 27216319
Our CHIP assay demonstrated that SUVH2 and SUVH9 are required for the occupancy of Pol V at RdDM loci and facilitate the production of Pol V-dependent noncoding RNAs PMID: 24465213
SUVH2 and SUVH9 functions in RdDM and TGS are overlapping. Pol V specific transcripts were reduced in suvh2 suvh9 plants. This might indicate a role of these SUVH proteins in Pol V complex recruitment. PMID: 22669745
SRA-domain proteins (SUVH2) are also essential for DRM2-mediated de novo and maintenance DNA methylation in Arabidopsis thaliana. PMID: 19043555
SUVH2 overexpression inhibits senescence-associated global changes in chromatin organization. PMID: 19143996

Hide All

Subcellular Location

Nucleus. Chromosome, centromere. Note=Associates with centromeric constitutive heterochromatin.

Protein Families

Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, Suvar3-9 subfamily

Tissue Specificity

Expressed at low levels in leaves stems and flowers.

Database Links

KEGG: ath:AT2G33290

STRING: 3702.AT2G33290.1

UniGene: At.12115

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SUVH2 Antibody

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