SWI6 Antibody

1. Swi4/Swi6 (SBF) factor binding at HO follows a temporal cascade, with SBF bound at upstream regulatory sequence (URS2-L) serving to relay a signal from URS1 to the SBF sites in URS2-R that ultimately activate gene expression. PMID: 25512608
2. study identifies a region of the carboxy terminus of Swi6 that is required for Nrm1 and Whi5 binding to their target transcription factors and show that mutation of this region overrides the repression of MBF- and SBF-regulated genes by Nrm1 and Whi5. PMID: 23382076
3. We found that the transcriptional cofactor Swi6p and activator Swi4p, as well as the G(2)/M-specific cyclin Clb2p, are required in a microtubule-destabilizing environment PMID: 22037179
4. oxidative stress signaling for cell cycle regulation occurs through oxidation of the G(1)/S-specific transcription factor Swi6p and consequently leads to suppression of the expression of G(1) cyclins and a delay in cells entering the cell cycle. PMID: 21147769
5. Data show that in Swi6 the structural and physical features of the nucleic acid binding interface have been completely eradicated. PMID: 20635421
6. Data show that Mpk1 negatively regulates Swi6 by phosphorylation on Ser238, which inhibits nuclear entry. PMID: 20219973
7. binding of the Swi4/Swi6 (SBF) transcription factors to an evolutionarily conserved site within the recombination enhancer PMID: 16809780
8. Swi6p is involved in oxidant sensing leading to cell division delay. PMID: 18205808
9. propose a model in which phosphorylated Mpk1 or Mlp1 forms a dimeric complex with Swi4 that is competent to associate with the FKS2 promoter PMID: 18268013
10. Identified the cell cycle-regulated SBF protein complex(Swi4/Swi6) as required for H3K79 dimethylation. PMID: 19682934

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KEGG: sce:YLR182W

STRING: 4932.YLR182W