SWI6 Antibody

1. rather than promoting maintenance and spreading of heterochromatin, Swi6 appears to limit these processes and appropriately confine heterochromatin. PMID: 26438724
2. binding of HP1 protein, Swi6, to methylated nucleosomes drives a switch from an auto-inhibited state to a spreading-competent state, where H3K9-methylated heterochromatin spreads to adjacent regions PMID: 23485968
3. HP1(Swi6) mediates the recognition and destruction of heterochromatic RNA transcripts PMID: 22683269
4. Mutations in Swi6 that disrupt cdc6 protein interaction disrupt silencing and delay replication in the centromere. PMID: 21239883
5. Our analyses suggest that Swi6/HP1 recruits opposing chromatin-modifying activities, the balancing of which is crucial for heterochromatin maintenance. PMID: 16762840
6. Binding of Swi6 within approx 50kb of the telomere occurs less in partial aneuploid strains compared to euploid strains of S. pombe. PMID: 18285637
7. These results provide insights into the regulation of siRNA action and reveal roles for cis-dsRNA synthesis and HP1 in siRNA-mediated heterochromatin assembly. PMID: 18657501
8. casein kinase II (CK2) phosphorylated Swi6 PMID: 19136623
9. Msc1, is a critical factor required for proper cell fate determination in S. pombe. PMID: 19164572
10. Swi6, an S. pombe counterpart of heterochromatin protein 1 (HP1), is required for early replication of the pericentromeric region and the mat locus. PMID: 19182789
11. These analyses suggest that among other functions, HP1 proteins associate with chromatin-modifying factors that in turn cooperate to assemble repressive chromatin; thus, precluding accessibility of underlying DNA sequences to transcriptional machinery. PMID: 19443688

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KEGG: spo:SPAC664.01c

STRING: 4896.SPAC664.01c.1