Sxl Antibody

1. Sxl is necessary for the cell-autonomous maintenance of germ cell female identity. PMID: 25758221
2. During evolution, Sxl managed to usurp the role of tra as the master regulator of sex determination relatively quickly in Drosophila's insect ancestors. PMID: 24191002
3. The maize 1-deoxy-D-xylulose 5-phosphate synthase genes display a particular tissue-specific expression that changes during plant development and in response to external signals. PMID: 21199890
4. study demonstrates that, in Drosophila, the Sex lethal (Sxl) gene acts autonomously in primordial germ cells to induce female development PMID: 21737698
5. Study shows that SXL controls a family of Drosophila mRNAs by regulation of upstream open reading frames (uORFs), and suggest that the underlying regulatory principle may apply more broadly to eukaryotic gene regulation PMID: 21663794
6. Drosophila Sxl may appear functionally female specific not because it lost non-female-specific functions, but because those functions are nonessential in the laboratory PMID: 20837995
7. sex-lethal is capable of direct physical interactions with chromosomes. This is consistent with the developmentally regulated nuclear localization of sex-lethal being important for oogenesis. PMID: 12000643
8. This protein promotes the skipping of exon 3 from its own pre-mRNA. Two AG dinucleotides and an intervening Py-tract at the 3'end of intron 2 are important for autoregulation. PMID: 12015979
9. Wolbachia restores fertility to Drosophila melanogaster mutant females prevented from making eggs by protein-coding lesions in Sex-lethal. PMID: 12097909
10. SEX-LETHAL protein acts after splice site recognition, but before catalysis begins, in male exon skipping. PMID: 12490553
11. Documents gutfeeling as a target and regulator of sex-lethal in early germ cells. PMID: 12645926
12. This material binds to the 3'UTR of msl-2 mRNA and activates the translational repressor domain, thereby enabling it to recruit co-repressors in a specific fashion. PMID: 14532129
13. hedgehog (Hh) promotes the entry of Sxl into the nucleus in the wing disc; In the anterior compartmentm Patched (Ptc) is required for this effect, revealing Ptc as a positive effector of Hh. PMID: 14597576
14. The inhibition of male-specific lethal 2 (msl-2) mRNA translation by the RNA-binding protein sex-lethal (SXL) is an essential regulatory step for X-chromosome dosage compensation in Drosophila melanogaster PMID: 16452509
15. Sxl transcript represents a novel target of Bruno-mediated translational repression required for cystoblast differentiation PMID: 17067567
16. Results show that Sex-lethal, Patched and Smoothened co-immunoprecipitate and co-fractionate, suggesting a large complex of both membrane and cytoplasmic components of the Hedgehog pathway. PMID: 17284519
17. The tra-mediated Sxl feedback in Drosophila may be a vestige of regulatory redundancy that facilitated the evolutionary transition from tra to Sxl as the master sex switch. PMID: 18845845

Show More

Hide All

KEGG: dme:Dmel_CG43770

STRING: 7227.FBpp0303712

UniGene: Dm.4502