syd-1 Antibody

Code CSB-PA769754XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans syd-1 Polyclonal antibody
Uniprot No.
Target Names
syd-1
Alternative Names
syd-1 antibody; F35D2.5 antibody; Rho GTPase-activating protein syd-1 antibody; Axon identity specification protein syd-1 antibody; Synapse defective protein 1 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans syd-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Probable GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Regulates the localization and assembly of presynaptic components during presynaptic development and is required for specifying the identity of axons during initial polarity acquisition. In these roles it is thought to act cell autonomously downstream of syg-1 and syg-2 and upstream of syd-2, possibly as a positive regulator of the latter. Required for the control of movement, egg-laying and the correct localization of elks-1.
Gene References into Functions
  1. SYD-1 and SYD-2 function cell-autonomously at presynaptic terminals, downstream of synaptic specificity molecule SYG-1. SYD-1 is likely to act upstream of SYD-2 to positively regulate its synaptic assembly activity. PMID: 17115039
  2. SYD-2, SYD-1 and UNC-10 were found essential for presynaptic site active zone assembly at synapses. PMID: 19436057
Subcellular Location
Cell junction, synapse.
Tissue Specificity
Expressed in the nerve ring of embryos. In L1 larvae, expression is seen in the ventral processes of ventral cord motor neurons. In adults, expression is seen along the dorsal and ventral nerve cords, the HSNL motor neuron and more specifically localizes
Database Links

KEGG: cel:CELE_F35D2.5

STRING: 6239.F35D2.5a

UniGene: Cel.22914

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