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syg-1 Antibody

Datasheet
Code CSB-PA557358XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans syg-1 Polyclonal antibody
Uniprot No.
B1Q236
Target Names
syg-1
Alternative Names
syg-1 antibody; K02E10.8 antibody; Synaptogenesis protein syg-1 antibody; Synaptogenesis abnormal protein 1 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans syg-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Cell adhesion protein. Involved in synapse formation in the HSNL egg-laying motor neuron. Inhibits assembly of the SCF(sel-10) E3 ubiquitin ligase complex at synapses, and protects them from elimination. Also required for F-actin assembly at the synaptic region and for axon branch formation.
Gene References into Functions
  1. Through a series of biochemical, biophysical, and in vivo functional experiments, study finds that the extracellular affinity, docking geometry, and rigidity of the SYG-1 and SYG-2 ectodomains play crucial roles in specifying a functional synaptic architecture in C. elegans. PMID: 24485456
  2. Assembly of the F-actin network requires a direct interaction between the synaptic cell adhesion molecule SYG-1 and a key regulator of actin cytoskeleton, the WVE-1/WAVE regulatory complex. PMID: 24439377
  3. Data show that the nephrin/Neph1 orthologs SYG-2 and SYG-1 form intercellular contacts strictly in trans between epithelial guidepost cells and neurons specifying the localization of synapses. PMID: 21858180
  4. SYG-2 binds SYG-1, the receptor on HSNL, and directs SYG-1 accumulation and synapse formation to adjacent regions of HSNL. PMID: 15035988
Subcellular Location
Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell junction, synapse.
Protein Families
Immunoglobulin superfamily
Tissue Specificity
Expression in head motor neurons, occasionally in HSN neurons and weakly in other cells in the vulval region. Expressed in the primary synapse region of HSNL motor neuron.
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