Serpine1 Antibody

1. PAI-1 induces alveolar type II cell senescence through activating p53-p21-Rb pathway in fibrotic lung disease. PMID: 28722352
2. PAI-1 is implicated in the pathophysiology of depression. PMID: 27456456
3. Our results demonstrate the antifibrotic effect of PTX on radiation-induced lung fibrosis and its effect on modulation of PKA and PAI-1 expression as possible antifibrotic mechanisms. PMID: 28337441
4. Paclitaxel at low non-cytotoxic doses ameliorates renal fibrosis by inhibiting multiple steps in the TGF-beta1-induced PAI-1 signaling including Smads and mitogen-activated protein kinases. PMID: 26869361
5. Aldosterone at different concentrations exerts synergistic effect with TGF-beta1 to increase PAI-1 expression in hepatic stellate cells PMID: 26617694
6. inhibition of ERK1/2 activation has no therapeutic effect on kidney fibrosis in SNx possibly due to increased compensatory activation of the p38 and JNK signalling pathways with subsequent upregulation of PAI-1. PMID: 26415098
7. These results suggest the critical physiological role of TRL4-Fyn interaction in the modulation of PAI-1-tPA axis in astrocytes during neuroinflammatory responses such as ischemia/reperfusion injuries. PMID: 25106729
8. these results suggested that TGF-beta1 and Serpine 1 overexpression might play an important role in DVT formation and have predictive values. PMID: 26535698
9. PAI-1 contributes to the regulation of the inflammatory response in alveolar macrophages. PMID: 25342286
10. Neurite extension effects of valproic acid are mediated by modulating the tPA/plasminogen activator inhibitor (PAI)-1 system. PMID: 23378038
11. Together, because CPAI blocks both proteolytic and nonproteolytic tPA neurotoxicity, it is a promising therapeutics of neonatal HI injury either with or without infection. PMID: 22556277
12. PAI-1 promotes the proliferation, transforming into myofibroblasts, collagen synthesis, and inhibits apoptosis of pulmonary fibroblasts by activating Ca(2+), ERK and AKT signaling pathway. PMID: 23021499
13. adhesion scores, PAI-1 activity in peritoneal lavage fluid, and PAI-1 mRNA levels in peritoneal mesothelium were significantly greater in the open surgery group than the control and laparoscopic surgery groups PMID: 23218127
14. This study supports that a preceding progesterone-enriched milieu prevented the enhanced prothrombotic risk induced by a fructose-rich diet-elicited high PAI-1 production. PMID: 23016136
15. down-regulation of PAI-1 and MMP-9 might contribute to abnormal programming of renal growth in rats exposed to postnatal early overnutrition PMID: 21752621
16. The data demonstrate that PAI-1 siRNA inhibits alveolitis and pulmonary fibrosis in bleomycin-treated rats via inhibiting the proliferation and promoting the apoptosis of fibroblasts. PMID: 22659625
17. mRNA, protein and activity of matrix metalloproteinase (MMP)-2 and MMP-9 and mRNA of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor 1 (PAI-1) were quantified in abdominal aorta (AA) and femoral artery (FA). PMID: 22071631
18. Hydrocortisone up-regulates PAI-1 expression in a tissue-specific manner along with down-regulation of tPA activity in both normal and inflammatory conditions. PMID: 21412817
19. The activity of tissue plasminogen activator peaks transiently and then decreases in cortex and striatum along with delayed induction of PAI-1 in the inflammatory stage after reperfusion injury. PMID: 21193004
20. Data suggest PAI1 plays key role in modulating chromaffin cell neurosecretory function. Evidence is presented that in chromaffin cells, PAI1 is targeted to storage vesicles and co-released with catecholamine upon secretagogue stimulation. PMID: 21596853
21. PAI-1 derived from the neurovascular unit and peripheral vascular system participates as a positive regulator of the blood-brain barrier in facilitating the barrier function of the endothelial tight junctions. PMID: 21036181
22. Erigeron breviscapus injection can inhibit the expression of TNF-alpha and PAI-1, and increase the expression of tPA in rats with acute myocardial infarction. PMID: 21355198
23. PAI-1 may play a protective role against cardiovascular disease in diabetes PMID: 20538356
24. Expression of u-PA/PAI-1 mRNA and protein increased during the early stage of hyperoxic exposure and decreased during the middle and late stage. PMID: 19099788
25. The results suggest that SHP inhibits PAI-1 expression in VSMCs through the suppression of TGF-beta/Smad3 and AP-1 activity. PMID: 19887897
26. High glucose decreased the expressions of tPA and uPA, and increased PAI1. Losartan could partly reverse partly this expression. PMID: 17953365
27. Dahuang Zhechong Pill can down-regulate the expressions of TIMP-1 and PAI-1 mRNAs in renal tissues of rats with focal segmental glomerulosclerosis. PMID: 18471418
28. Inactivation of PAI-1 speeds lysis of a platelet-rich clot in rat mesenteric arterioles. Active PAI-1 participates in arteriolar microcirculation resistance to thrombolysis and its inactivation may shorten ischemic periods after microvascular obstruction. PMID: 11776323
29. The hexosamine pathway regulates the plasminogen activator inhibitor-1 gene promoter and Sp1 transcriptional activation through protein kinase C-betaI and -delta. PMID: 12105191
30. pathways of regulation of PAI1 induction and secretion by growth factors bFGF and PDGF in smooth muscle cells PMID: 12192306
31. Data show that recovery from obstruction-induced renal fibrosis was correlated with diminished expression of TGF-beta, collagen IV, and plasminogen activator inhibitor-1. PMID: 12365557
32. HIF1a and hypoxia response elements mediate the induction of PAI-1 gene expression by insulin via the PI3K/PKB pathway in primary rat hepatocytes. PMID: 12393531
33. possible role as the neurotrophic factor PMID: 12491782
34. Expression of functionally active PN-1 has been examined in vitro in rat aortic smooth muscle cells and in vivo in rat arterial media and its regulation in hypertensive rats. PMID: 12524238
35. Northern analysis confirmed upregulation of PAI-1, P2X4, and P15INK4B in cultured alveolar epithelial type I cells (AT1); in whole lung, all three proteins were detected in alveolar epithelium in a location consistent with expression in AT1 cells PMID: 12600825
36. hypoxia-dependent plasminogen activator inhibitor 1 expression is regulated by MAP kinases PMID: 12669121
37. In cells expressing RacG12V, ROS production was increased and PAI-1 mRNA levels as well as HIF-alpha nuclear presence were reduced under normoxia and hypoxia; whereas expression of RacT17N resulted in decreased ROS production and opposite effects. PMID: 12719791
38. Enhanced expression of clock genes may increase PAI-1 expression in concert with activated renin-angiotensin system in SHR heart PMID: 12777947
39. after transient focal cerebral ischemia, there are time dependent changes in PAI-1 expression PMID: 14512838
40. cellular carbonyl stress may stimulate PAI-1 synthesis in and release from adipose tissues through ROS formation PMID: 14610081
41. Pai1 expression is required for epithelial cell migration in in vitro wound healing. PMID: 15174100
42. PAI-1 and TGF-beta 1 in carotid glomus and autonomic ganglia were significantly increased (P < 0.01) in hypertensive rats PMID: 15201552
43. Altered expression of Pai-1 in diabetic nephropathy was associated with mesangial expansion. PMID: 15322501
44. Regression of glomerulosclerosis was linked to decreased tissue inhibitor of metalloproteinase-1 and plasminogen activator inhibitor-1. PMID: 15728787
45. Cardiac PAI-1 gene expression regulation is mediated through c-Jun NH2-terminal kinase activation. PMID: 15808835
46. the essential requirement of MAPK/AP-1 activation for TGF-beta1-induced PAI-1 expression is unique to rat mesangial cells PMID: 16105028
47. A dual role for PAI-1 in epithelial cell wound healing, both as a soluble inhibitor of proteolysis and also as a matrix-bound regulator of cell migration, is proposed. PMID: 17071586
48. This study indicate that aldosterone can increase PAI-1 mRNA and protein expression by cultured mesangial cells alone, which is independent of aldosterone-induced increases in TGF-beta(1) expression and cellular reactive oxygen species. PMID: 17394767
49. Renin induces ERK1/2 activation. Renin-activated pathway triggers cell proliferation along with TGF-beta1 and plasminogen activator inhibitor-1 gene expression. PMID: 17396111
50. PAI-1 plays a role in the occurrence of liver failure after excessive hepatectomy via accelerated maturation of pro-uPA and fibrinolytic factors. PMID: 17655862

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KEGG: rno:24617

STRING: 10116.ENSRNOP00000001916

UniGene: Rn.29367