tdp-1 Antibody

Datasheet

Code	CSB-PA965931XA01CXY
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Product Details
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans tdp-1 Polyclonal antibody

Uniprot No.

D0VWM8

Target Names

tdp-1

Alternative Names

tdp-1 antibody; F44G4.4 antibody; Tar DNA-binding protein homolog 1 antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans tdp-1 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

RNA-binding protein which regulates transcription, splicing and RNA-editing. Limits the accumulation of double-stranded RNA by maintaining the abundance of the mature RNA transcripts that are formed from double-stranded precursor RNAs. Stress response protein that acts downstream of daf-16 in the insulin/IGF pathway to regulate longevity and the cellular stress response to osmotic, oxidative, proteotoxic and endoplasmic reticulum stress. Involved in the regulation of physiological processes including aging, fertility, growth and locomotion.

Gene References into Functions

TDP-1 regulates lifespan and proteotoxicity through DAF-16. PMID: 25329970
These data show that the primary function of TDP-1, an ortholog of the neurodegeneration-associated RNA-binding protein TDP-43, is to limit formation or stability of double-stranded RNA. PMID: 25391662
It causes age-dependent toxicity to motor neurons. PMID: 23591130
These results suggest that chronic induction of wild-type TDP-1/TDP-43 by cellular stress may propagate neurodegeneration and decrease lifespan. PMID: 22792076

Subcellular Location

Nucleus. Cytoplasm.

Tissue Specificity

Widely expressed in a range of tissues including body wall muscles, pharynx and neurons of the midbody in adults and larvae.

Database Links

KEGG: cel:CELE_F44G4.4

STRING: 6239.F44G4.4c

UniGene: Cel.15106

Promotions

Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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