Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans tat-1 Polyclonal antibody

Uniprot No.

Q9U280

Target Names

tat-1

Alternative Names

tat-1 antibody; Y49E10.11 antibody; Phospholipid-transporting ATPase tat-1 antibody; EC 7.6.2.1 antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans tat-1 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Transports phosphatidylserine from the outer to the inner leaflet of the plasma membrane, thereby maintaining the enrichment of this phospholipid in the inner leaflet. Ectopic exposure of phosphatidylserine on the cell surface may result in removal of living cells by neighboring phagocytes. Regulation of the phosphatidylserine distribution in plasma membranes is likely to help in the maintenance and control of the membrane surface charge. Plays a role in the formation of the tubular membrane structure and in membrane trafficking and is specifically involved in the recycling and degradation of endocytic cargo, likely with its chaperone protein chat-1.

Gene References into Functions

Disruption of phosphatidylserine asymmetry by tat-1 mutation leads to redistribution of positively charged biosensors from plasma membranes to endomembranes. PMID: 23427264
TAT-1 is differentially spliced during development and that TAT-1C-specific splicing occurs in the intestine where NUM-1A is known to function. PMID: 21917090
CHAT-1 and TAT-1 maintain membrane phosphatidylserine asymmetry, thus promoting membrane tubulation and regulating endocytic sorting and recycling. PMID: 21170358
Apoptosis, triggered by cell surface phosphatidylserine exposure, requires a functional TAT1 protein. PMID: 17540571
study reports that TAT-1 is critical for maintaining cell surface asymmetry of phosphatidylserine (PS); tat-1 appears to function in preventing appearance of PS in the outer leaflet of plasma membrane PMID: 18436785
TAT-1 is required at multiple steps of the endolysosomal pathway, at least in part by ensuring proper trafficking of cell-specific effector proteins PMID: 18939953

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Subcellular Location

Cell membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein.

Protein Families

Cation transport ATPase (P-type) (TC 3.A.3) family, Type IV subfamily

Database Links

KEGG: cel:CELE_Y49E10.11

STRING: 6239.Y49E10.11c.2

UniGene: Cel.17289

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tat-1 Antibody

Product Details

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Target Background