tax Antibody

Code CSB-PA365933XA01HQL
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Product Details

Full Product Name
Rabbit anti-Human T-cell leukemia virus 2 (HTLV-2) tax Polyclonal antibody
Uniprot No.
Target Names
tax
Alternative Names
tax antibody; Protein Tax-2 antibody; Trans-activating transcriptional regulatory protein of HTLV-2 antibody
Raised in
Rabbit
Species Reactivity
Human T-cell leukemia virus 2 (HTLV-2)
Immunogen
Recombinant Human T-cell leukemia virus 2 (HTLV-2) tax protein
Immunogen Species
Human T-cell leukemia virus 2 (HTLV-2)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Transcriptional activator that activates both the viral long terminal repeat (LTR) and cellular promoters via activation of CREB, NF-kappa-B, SRF and AP-1 pathways. Binds to three 21 bp repeat elements located within the LTRs, referred to as Tax-responsive elements (TRE). Binding to TRE requires the interaction with CREB1 and CREBBP. Induces T-cell transformation, although much less efficiently than HTLV-1. Required for viral replication.
Gene References into Functions
  1. A Luciferase Functional Quantitative Assay for Measuring NF-kB Promoter Transactivation Mediated by HTLV-1 and HTLV-2 Tax Proteins.( PMID: 28357663
  2. the role of Tax2-mediated activation of the nuclear factor kappa B (NF-kappaB) signalling pathway on the production of the anti-viral CC-chemokines MIP-1alpha, MIP-1beta and RANTES. PMID: 24116893
  3. In natural HTLV-1 infection cells expressing HTLV-1 Tax protein were significantly more frequent in clones of low abundance in vivo. PMID: 23555266
  4. The authors demonstrate that a nonubiquitinable, non-SUMOylable, and nonacetylable human T cell leukemia virus type 2 tax mutant retains a significant ability to activate transcription from a NF-kappaB-dependent promoter. PMID: 23135727
  5. HTLV-1 Tax1 and HTLV-2 Tax2 have many shared activities, but have a number of significantly distinct activities that appear to play key roles in HTLV-1 specific pathogenesis. We emphasize special attention to distinctions between Tax1 and Tax2. [REVIEW] PMID: 20017952
  6. These results show that HTLV-2 Tax2 by itself has a growth promoting activity toward a T-cell line CTLL-2 growth of Tax2-transformed CTLL-2 cells. These results show that HTLV-2 Tax2 by itself has a growth promoting activity toward a T-cell line CTLL-2. PMID: 17140451
  7. The authors demonstrate that Tax-2B is modified by ubiquitination and sumoylation. PMID: 19195675
  8. Virus-specific cytotoxic T cell responses against HTLV-2 Tax protein in HTLV-2 infection are characterized for the first time. PMID: 19657093

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Subcellular Location
Host cytoplasm. Host nucleus. Note=Tax-2 is mainly found in the cytoplasm.
Protein Families
Deltaretrovirus Tax protein family
Database Links

KEGG: vg:1491946

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