tax Antibody

Code CSB-PA606718XA01FZF
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Product Details

Full Product Name
Rabbit anti-Human T-cell leukemia virus 3 (strain 2026ND) (HTLV-3) tax Polyclonal antibody
Uniprot No.
Target Names
tax
Alternative Names
tax antibody; Protein Tax-3 antibody; Trans-activating transcriptional regulatory protein of HTLV-3 antibody
Raised in
Rabbit
Species Reactivity
Human T-cell leukemia virus 3 (strain 2026ND) (HTLV-3)
Immunogen
Recombinant Human T-cell leukemia virus 3 (strain 2026ND) (HTLV-3) tax protein
Immunogen Species
Human T-cell leukemia virus 3 (strain 2026ND) (HTLV-3)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Transcriptional activator that activates both the viral long terminal repeat (LTR) and cellular promoters via activation of CREB, NF-kappa-B, SRF and AP-1 pathways. Binds to two 21 bp repeat elements located within the LTRs, referred to as Tax-responsive element (TRE). Binding to TRE requires the interaction with CREB1 and CREBBP. Activation of NF-kappa-B leads to up-regulation of the expression of gene promoters containing NFkB motifs like IL8 or BCL2L1. Inhibits the action of p53/TP53 and MYCB. All these functions could lead to the possible occurrence of lymphoproliferative disorders. Required for viral replication.
Subcellular Location
Host nucleus. Host cytoplasm.
Protein Families
Deltaretrovirus Tax protein family
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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