Tbp Antibody

Code CSB-PA023239XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Tbp Polyclonal antibody
Uniprot No.
Target Names
Tbp
Alternative Names
Tbp antibody; BTF1 antibody; TFIID antibody; CG9874 antibody; TATA-box-binding protein antibody; TATA sequence-binding protein antibody; TATA-binding factor antibody; TATA-box factor antibody; Transcription initiation factor TFIID TBP subunit antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Tbp protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.
Gene References into Functions
  1. TFIID has two disctinct modes of transcription initiation, de novo initiation and reinitiation, as revealed by the inhibitory effect of TFIID-bound tin compounds on the de novo initiation, but not on the reinitiation. PMID: 26314865
  2. Deactivation of TBP contributes to SCA17 pathogenesis. PMID: 25104854
  3. Aptamers generated by both selections were able to bind specifically to TBP, but the two groups showed characteristics which were clearly different in terms of their capability to compete with TATA-DNA. PMID: 23924740
  4. Tbp targets core histone transcription. PMID: 17978101
Subcellular Location
Nucleus.
Protein Families
TBP family
Database Links

KEGG: dme:Dmel_CG9874

STRING: 7227.FBpp0071596

UniGene: Dm.4490

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