tbx-2 Antibody

Code CSB-PA613903XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans tbx-2 Polyclonal antibody
Uniprot No.
Target Names
tbx-2
Alternative Names
tbx-2 antibody; F21H11.3 antibody; T-box protein 2 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans tbx-2 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Involved in the transcriptional regulation of genes required for the development of pharyngeal muscles derived from the ABa lineage. Acts as a transcriptional repressor and binds to T-box binding sites in its own promoter to negatively autoregulate its own expression in neurons, seam cells and the gut in order to restrict its expression to certain tissues. May function together with the nfya-1-NF-Y complex to repress its own expression.
Gene References into Functions
  1. Reduction of SUMOylation enhances the effect of a tbx-2 hypomorphic mutant on embryonic viability and pharyngeal muscle development, and that repression of a downstream target of TBX-2 depends on SUMOylation. PMID: 23595631
  2. Ce-TBX-2, the TBX2/TBX3 transcriptional factor homologue of the nematode Caenorhabditis elegans, is involved in olfactory adaptation PMID: 14750151
  3. TBX-2 and SUMO-conjugating enzymes are necessary for ABa-derived pharyngeal muscle, and we hypothesize that TBX-2 function requires sumoylation. PMID: 16701625
  4. The analysis suggests that a positive feedback loop between tbx-2 and pha-4 is required for blastomere-derived precursors to commit to pharyngeal muscle fate. PMID: 17005176
  5. In screens for mutants with abnormal HSN motor neuron development, we identified the T-box protein TBX-2 as being important for both HSN and PHB sensory neuron differentiation. PMID: 18505863

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Subcellular Location
Nucleus.
Tissue Specificity
Expressed in body wall muscles and a subset of pharyngeal neurons. Expressed in head neurons and occassionally tail neurons. Not expressed in the pharynx.
Database Links

KEGG: cel:CELE_F21H11.3

STRING: 6239.F21H11.3

UniGene: Cel.8043

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