TCEA2 Antibody

Code CSB-PA621877ZA01HU
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TCEA2 Polyclonal antibody
Uniprot No.
Target Names
TCEA2
Alternative Names
Tcea2 antibody; TCEA2_HUMAN antibody; Testis specific S II antibody; Testis-specific S-II antibody; TFIIS antibody; Transcription elongation factor A (SII) 2 antibody; Transcription elongation factor A 2 antibody; Transcription elongation factor A protein 2 antibody; Transcription elongation factor S II protein 2 antibody; Transcription elongation factor S-II protein 2 antibody; Transcription elongation factor TFIIS.1 antibody; Transcription elongation factor TFIIS.l antibody
Raised in
Rabbit
Species Reactivity
Homo sapiens
Immunogen
Recombinant Homo sapiens TCEA2 protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (12-14 weeks)

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Target Background

Function
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
Gene References into Functions
  1. RNA polymerase II complexes in the very early phase of transcription are not susceptible to TFIIS-induced exonucleolytic cleavage. PMID: 12034815
  2. data suggest that because TFIIS promotes escape from promoter-proximal pauses by stimulating cleavage of back-tracked nascent RNA, TFIIS inhibition may help DSIF/NELF negatively regulate productive transcription PMID: 16214896
  3. SII is important for preventing cellular death due to oxidative DNA damage, assisting RNAPII to bypass 8-oxoG PMID: 17374514
Subcellular Location
Nucleus.
Protein Families
TFS-II family
Tissue Specificity
Testis and ovary specific.
Database Links

HGNC: 11614

OMIM: 604784

KEGG: hsa:6919

STRING: 9606.ENSP00000343515

UniGene: Hs.505004

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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