Product Details

Full Product Name

Rabbit anti-Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) tea1 Polyclonal antibody

Uniprot No.

P87061

Target Names

tea1

Alternative Names

tea1 antibody; alp8 antibody; SPCC1223.06 antibody; Tip elongation aberrant protein 1 antibody; Altered polarity protein 8 antibody; Cell polarity protein tea1 antibody

Raised in

Rabbit

Species Reactivity

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Immunogen

Recombinant Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) tea1 protein

Immunogen Species

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Cell polarity protein. Acts as an end marker, directing the growth machinery to the cell poles. Involved in the regulation of microtubular organization, affecting the maintenance of a single central axis. Prevents the curling of microtubule tips around the cell ends and is required for the retention of polarity factors such as pom1, tip1 and tea2 at the cell ends, necessary for the cell to grow in a straight line. Links tip1 and tea4 in a common complex.

Gene References into Functions

Study proposes that Cki3 monitors the timing of growth polarity transition from monopolar to bipolar during G2 phase onset through Tea1 phosphorylation by regulating the interaction between Tea1 and Tea4. PMID: 26525038
Study constructed fission yeast strains exhibiting depressed microtubule dynamics by mutating the beta-tubulin gene, nda3. This interfered with efficient accumulation of a polarity factor Tea1 at cell tips. PMID: 21548112
Data suggest that rather than acting simply as a Tea1 receptor or as a molecular "glue" to retain Tea1, Mod5 functions catalytically to stimulate incorporation of Tea1 into a stable tip-associated cluster network. PMID: 20850323
End4/Sla2 acts downstream of the polarity marker Tea1 and is implicated in the recruitment of the actin cytoskeleton to bring about polarised cell growth PMID: 15827087
results suggest that independent protein-protein interactions among tea1p, tea3p and mod5p collectively contribute to tea1p anchoring at cell tips via a multistep and multimode mechanism PMID: 16222337
nuclear centering becomes essential when Pom1/Tea1/Tea4 function is compromised and that Kin1 expression level is a key regulatory element in this situation PMID: 19597328

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Subcellular Location

Cytoplasm, cytoskeleton. Note=Present at both poles of the cell throughout the cell cycle whether they are growing or not. Located at the ends of microtubules growing towards the cell poles. An intact microtubular skeleton is required to maintain the location at the cell tips; on the other hand, a normally organized actin cytoskeleton is not required.

Database Links

KEGG: spo:SPCC1223.06

STRING: 4896.SPCC1223.06.1

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tea1 Antibody

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