Ten-a Antibody

Code CSB-PA808854XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Ten-a Polyclonal antibody
Uniprot No.
Target Names
Ten-a
Alternative Names
Ten-a antibody; CG42338 antibody; Teneurin-a antibody; Tena antibody; Tenascin-like protein antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Ten-a protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Acts as a homophilic and heterophilic synaptic cell adhesion molecule that drives synapse assembly. Promotes bi-directional trans-synaptic signaling with ten-m to organize neuromuscular synapses.
Gene References into Functions
  1. Ten-a acts in olfactory receptor neurons to organize presynaptic active zones via the spectrin cytoskeleton. PMID: 25310239
  2. Our result revealed the function of ten-a in central brain development, and possible cellular mechanism underlying Drosophila fan-shaped body formation. PMID: 23437330
  3. identification of two evolutionarily conserved, epidermal growth factor (EGF)-repeat containing transmembrane Teneurin proteins, Ten-m and Ten-a, as synaptic-partner-matching molecules between projection neuron dendrites and olfactory receptor neuron axons PMID: 22425994
  4. study identifies the Teneurins as a key bi-directional trans-synaptic signal involved in general synapse organization, and demonstrates that proteins such as these can also regulate target selection PMID: 22426000
  5. The Ten-a protein, a dimeric receptor of about 500 kDa is mainly expressed on axons of the embryonic central nervous system and on muscle attachment sites PMID: 12175511

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Subcellular Location
Cell projection, axon. Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, synaptosome. Membrane; Single-pass membrane protein. Note=Localizes in the cell body and axon of neuronal cells. Localizes at neuromuscular junction.
Protein Families
Tenascin family, Teneurin subfamily
Database Links

KEGG: dme:Dmel_CG42338

STRING: 7227.FBpp0289137

UniGene: Dm.147

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