TER94 Antibody

1. rescue experiments with a lethal mfap1 mutant show that the VCP binding region is not essential for Mfap1 function, but may act to increase its stability or activity PMID: 28837687
2. results have revealed SUMOylation as a molecular signaling switch to regulate the distribution and functions of VCP during stress response, and suggest that deficiency in VCP SUMOylation caused by pathogenic mutations will render cells vulnerable to stress insults. PMID: 27226613
3. The authors propose that VCP sustains sarcoplasmic proteostasis, in part, by controlling the integrity of a dynamic tubular lysosomal network. PMID: 26167652
4. Ter94/VCP appears to be an evolutionarily conserved component that regulates BMP-Smad1/5/8 signaling. PMID: 25469707
5. Data identifies that ter94, Drosophila VCP, as a strong modulator of motor neuron degeneration induced by knockdown of Caz, Drosophila FUS PMID: 24497576
6. Valosin-Containing Protein has an essential role in dendrite pruning through regulating mRNA metabolism PMID: 24799714
7. VCP was validated as an atlastin-interacting protein. PMID: 23790629
8. Ter94 ATPase and K11-linked ubiquitination in Ci contribute to the selectivity by proteasomes for partial degradation. PMID: 23747190
9. VCP binds to DIAP1 in a ubiquitin- and BIR domain-dependent manner and facilitates its degradation, therefore, establishing a new link between ubiquitin, dendrite pruning and the apoptosis machinery. PMID: 21343367
10. Subcellular localization and ATPase activity of VCP clearly influenced the localization of the aggregates throughout the cells. PMID: 20604808
11. Genetic inactivation of ter94 increased the levels of misfolded Rh1 in retina. PMID: 20865169

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KEGG: dme:Dmel_CG2331

STRING: 7227.FBpp0111818

UniGene: Dm.2968