A Antibody

Code CSB-PA361130XA01FSF
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Product Details

Full Product Name
Rabbit anti-Escherichia phage lambda (Bacteriophage lambda) A Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
A antibody; lambdap02Terminase antibody; large subunit antibody; DNA-packaging protein A antibody; Large terminase protein antibody; gpA) [Includes: Endonuclease antibody; EC; Helicase antibody; EC; ATPase antibody; EC 3.6.4.-)] antibody
Raised in
Species Reactivity
Escherichia phage lambda (Bacteriophage lambda)
Recombinant Escherichia phage lambda (Bacteriophage lambda) A protein
Immunogen Species
Escherichia phage lambda (Bacteriophage lambda)
Purification Method
Antigen Affinity Purified
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Tested Applications
ELISA, WB (ensure identification of antigen)
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

The terminase large subunit acts as an ATP driven molecular motor necessary for viral DNA translocation into empty capsids and as an endonuclease that cuts the viral genome from the concetamer to initiate and to end the packaging reaction. The terminase lies at a unique vertex of the procapsid and is composed of two subunits, a small terminase subunit involved in viral DNA recognition (binding to packaging sequence cos), and a large terminase subunit possessing endonucleolytic, ATPase and helicase activities (DNA maturation and packaging). The terminase binds cooperatively with the host factor IHFA/IHFB to the cos site at the junction of adjacent viral genomes. The endonuclease activity cleaves the viral DNA generating 5'overhangs of 12 bp in length. The helicase activity separates the cohesive ends generating the single-stranded 'sticky' ends of the mature genome. IHFA/IHFB is also necessary for the strand separation activity of the terminase. The terminase remains bound to the left end of the genome to be packaged, forming a stable DNA-terminase complex. In a reaction facilitated by the viral assembly catalyst gpFI, the DNA-terminase complex binds to the portal of the procapsid thereby activating the translocase activity of the terminase. The terminase packages the viral DNA into the procapsid until the next cos site on the concatemer reaches the complex. The downstream cos site is then cut generating the mature right end of the genome, the heterotrimer undocks from the DNA-filled head and remains bound to the left end of concatemer's next genome.
Gene References into Functions
  1. In sum, bp -2 to 5 are critical for cosN function, and bp 6-12 of the cohesive end sequence are not critical for terminase recognition or virus fitness. PMID: 28646648
  2. The authors have been able to show that the terminase motor of phage lambda is able to produce infectious particles with up to 110% of the wild-type lambda-DNA length. PMID: 22108169
Subcellular Location
Host cytoplasm.
Protein Families
Lambdalikevirus large terminase family
Database Links

KEGG: vg:2703524

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