Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans dpl-1 Polyclonal antibody

Uniprot No.

Q22703

Target Names

dpl-1

Alternative Names

dpl-1 antibody; T23G7.1 antibody; Transcription factor dpl-1 antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans dpl-1 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription. May also negatively regulate vulval development in association with other SynMuv class B proteins such as lin-15A. Can stimulate E2F-dependent transcription. Plays a role in negatively regulating the progression through the G1 phase of the cell cycle during postembryonic development, most likely by acting as a transcriptional repressor in association with the cell cycle regulatory factor efl-1 and the transcriptional repressor lin-35, but may also act as a positive regulator of cell cycle entry. Involved in the regulation of intestinal cell division during postembryonic development, most likely in complex with efl-1 and lin-35. Promotes germ cell programmed cell death, probably together with efl-1, by positively regulating the expression of the apoptosis proteins ced-3 and ced-4. In particular, positively regulates the expression of ced-4 in response to starvation. Its role in programmed cell death may be in conjunction with cell cycle regulatory factor efl-1 and the synthetic multivulva class B proteins lin-35, lin-37 and lin-52, and is independent of the ced-1, ced-8 and ced-9 pathways.

Gene References into Functions

DPL-1 transcriptional activity inhibits CDK-2 mRNA accumulation in C. elegans germline stem cells, which leads to slower S-phase entry and progression. PMID: 29695611
Many EFL-1/DPL-1 responsive genes encode proteins required for oogenesis and early embryogenesis, rather than cell cycle components. PMID: 16854972
identified mutations in two genes not previously known to affect cell death, dpl-1 and mcd-1 (modifier of cell death) PMID: 17237514
DPL-1 and EFL-1, but not LIN-35, promote the expression of a negative regulator of MPK-1, the MAP kinase phosphatase LIP-1. PMID: 18304523
DPL-1 acts with EFL-1 in developing oocytes to directly regulate a transcriptional program that couples the critical events of ovulation and fertilization. PMID: 19368797

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Subcellular Location

Nucleus.

Protein Families

E2F/DP family

Database Links

KEGG: cel:CELE_T23G7.1

STRING: 6239.T23G7.1.1

UniGene: Cel.19382

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dpl-1 Antibody

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