Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans trx-1 Polyclonal antibody

Uniprot No.

Q09433

Target Names

trx-1

Alternative Names

trx-1 antibody; B0228.5 antibody; Thioredoxin-1 antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans trx-1 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Shown to facilitate the reduction of insulin disulfide bonds. Might play a role in the reversible nitrosylation of cysteine residues in target proteins, and thereby contributing to the response to intracellular nitric oxide. Shapes the ASJ sensory neuron biphasic response to nitric oxide (NO) exposure; trans-nitrosylation activity might inhibit calcium flux to the cytoplasm in ASJ neurons when exposed to a NO stimulus, whereas de-nitrosylation activity might promote calcium flux when NO is diminished. By regulating the NO-induced ASJ sensory neuron activity, mediates the avoidance response to NO-producing organisms like P.aeruginosa. Positively regulates life span extension under normal and caloric restriction conditions, dauer formation and the oxidative stress response. Contributes to the down-regulation of expression of the insulin-like neuropeptide daf-28 in the ASJ neurons in a redox-independent fashion, thereby promoting dauer formation. Negatively regulates the nuclear localization of the intestinal skn-1 transcription factor in a p38 MAPK pathway-dependent and redox-independent fashion.

Gene References into Functions

Trx-1 regulates intestinal SKN-1 nuclear localization in a cell non-autonomous manner. PMID: 26920757
TRX-1 is a thioredoxin homolog. Worms lacking this gene display reduced life span and sensitivity toward oxidative stress. PMID: 16324156
TRX-1 acts as a fluctuating neuronal signaling modulator within ASJ neurons to monitor the adjustment of neuropeptide expression, including insulin-like proteins, during dauer formation in response to adverse environmental conditions. PMID: 21304598
Dietary restriction activates TRX-1 in ASJ neurons during aging, which in turn triggers TRX-1-dependent mechanisms to extend adult lifespan in the worm. PMID: 21334311
Suppression of the C. elegans thioredoxin orthologs trx-1 and trx-2, involved in the redox chaperone activity of exo-3, overrides the protective effect of cep-1 RNAi treatment on neuronal integrity, neuronal function, mean and maximum life span. PMID: 20346071
Data describe a Caenorhabditis elegans thioredoxin (TRX-1), encoded by the gene B0228.5, that is expressed in ASJ ciliated sensory neurons. PMID: 16387300

Hide All

Protein Families

Thioredoxin family

Tissue Specificity

Expressed in ASJ and ASI ciliated sensory neurons. Expressed in the intestine (at protein level).

Database Links

KEGG: cel:CELE_B0228.5

STRING: 6239.B0228.5a

UniGene: Cel.16076

Message

Product >> Product Name：
Product >> Code：
Name： *
Email： *
Company/Organization：
Phone：
Since emails may get flagged by spam filters occasionally, we recommend leaving your phone number as a precaution. Your information is safe with us.
Question/Comment： *
Your Region： *
I'd like to receive email newsletters from Cusabio

Yes

No
How do you know CUSABIO?

Email

Distributor

Search engine

Advertisement

Others
CAPTCHA verification：

Code	CSB-PA601002XA01CXY
Size	Enquire
Have Questions?	Leave a Message or Start an on-line Chat

trx-1 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background