dhd Antibody

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Code	CSB-PA342129XA01DLU
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Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) dhd Polyclonal antibody

Uniprot No.

P47938

Target Names

dhd

Alternative Names

dhd antibody; Trx-1 antibody; CG4193 antibody; Thioredoxin-1 antibody; DmTrx-1 antibody; Protein deadhead antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) dhd protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. As a reducing substrate of peroxiredoxin 1, thioredoxin 2 is preferred over thioredoxin 1. Required for female meiosis and early embryonic development.

Gene References into Functions

This study demonstrates that DHD localizes to the sperm nucleus to reduce its disulfide targets and is then rapidly degraded after fertilization. PMID: 27876811
thioredoxin DHD plays a critical role in early development to facilitate the switch from protamine-based sperm chromatin structures to the somatic nucleosomal chromatin. PMID: 28031247
evidence for distinct biological function of Trx-1 PMID: 11877442
dimer dissociation constants K(d) were found to be 2.2mM for reduced DmTrx and above 10mM for oxidized DmTrx as well as for the protein in the presence of reduced glutathione PMID: 15644209

Subcellular Location

Nucleus.

Protein Families

Thioredoxin family

Tissue Specificity

Ovary specific. Expressed present in the nurse cells from stage 9 of ovary development and is transported into the oocyte. Expressed throughout oogenesis.

Database Links

KEGG: dme:Dmel_CG4193

STRING: 7227.FBpp0070717

UniGene: Dm.2955

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Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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dhd Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background