dhd Antibody

Code CSB-PA342129XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) dhd Polyclonal antibody
Uniprot No.
Target Names
dhd
Alternative Names
dhd antibody; Trx-1 antibody; CG4193 antibody; Thioredoxin-1 antibody; DmTrx-1 antibody; Protein deadhead antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) dhd protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. As a reducing substrate of peroxiredoxin 1, thioredoxin 2 is preferred over thioredoxin 1. Required for female meiosis and early embryonic development.
Gene References into Functions
  1. This study demonstrates that DHD localizes to the sperm nucleus to reduce its disulfide targets and is then rapidly degraded after fertilization. PMID: 27876811
  2. thioredoxin DHD plays a critical role in early development to facilitate the switch from protamine-based sperm chromatin structures to the somatic nucleosomal chromatin. PMID: 28031247
  3. evidence for distinct biological function of Trx-1 PMID: 11877442
  4. dimer dissociation constants K(d) were found to be 2.2mM for reduced DmTrx and above 10mM for oxidized DmTrx as well as for the protein in the presence of reduced glutathione PMID: 15644209
Subcellular Location
Nucleus.
Protein Families
Thioredoxin family
Tissue Specificity
Ovary specific. Expressed present in the nurse cells from stage 9 of ovary development and is transported into the oocyte. Expressed throughout oogenesis.
Database Links

KEGG: dme:Dmel_CG4193

STRING: 7227.FBpp0070717

UniGene: Dm.2955

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