Product Details

Full Product Name

Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) THO1 Polyclonal antibody

Uniprot No.

Q93VM9

Target Names

THO1

Alternative Names

THO1 antibody; EMU antibody; HPR1 antibody; At5g09860 antibody; MYH9.7 antibody; THO complex subunit 1 antibody; AtTHO1 antibody; HPR1 homolog antibody; AtHPR1 antibody

Raised in

Rabbit

Species Reactivity

Arabidopsis thaliana

Immunogen

Recombinant Arabidopsis thaliana THO1 protein

Immunogen Species

Arabidopsis thaliana (Mouse-ear cress)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export. Contributes to the integrity of the endogenous trans-acting small interfering RNA (ta-siRNA) pathway. May process or transport a long RNA molecule so that it can be a template for secondary siRNA production. May participate in the trafficking of siRNA precursors to the ARGONAUTE catalytic center. Required for the generation of functional messenger ribonucleoproteins (mRNPs). Plays an important roles in plant innate immunity.

Gene References into Functions

THO1 is required for scopolin accumulation in roots induced by sucrose.THO1 is part of the THO/TREX complex, which contributes to RNA silencing, supposedly by trafficking precursors of small RNAs. PMID: 29222952
THO/TREX complex is involved in mRNA export and miRNA biogenesis in Arabidopsis. THO/TREX complex negatively regulates root-associated APase activity by suppressing ethylene signaling. [AtTHO1] PMID: 27329222
Study identified the role of LON2 protease and the photorespiratory enzyme HPR1 in drought resistance. PMID: 26368942
Gene expression involved in ethylene signaling suppression was not reduced by the hpr1-5 mutation, which indicates selectivity of HPR1 for RTE1 expression affecting the consequent ethylene response. [HPR1] PMID: 25680185
HPR1 encodes a putative component of the THO/TREX complex that localizes to the nucleus and plays an important role in plant innate immunity. PMID: 22035198
HPR1 and TEX1 participate in the trafficking of siRNA precursors to the ARGONAUTE catalytic center. PMID: 20798330
Study identified and characterized a mutant gene named erecta mRNA under-expressed (emu)at At5g09860 that leads to the defective mRNA accumulation of ERECTA, a developmental regulator in the model plant Arabidopsis thaliana. PMID: 20668032

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Subcellular Location

Nucleus.

Database Links

KEGG: ath:AT5G09860

STRING: 3702.AT5G09860.1

UniGene: At.27041

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THO1 Antibody

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Target Background