Tip60 Antibody

1. most HIF1A targets require either TIP60, the CDK8-Mediator complex, or both as coactivators for full expression in hypoxia. PMID: 27320910
2. Our results implicate Tip60 as a critical mediator of EE-induced benefits, and provide broad insights into synergistic behavioral and epigenetic based therapeutic approaches for treatment of cognitive disorder. PMID: 27454757
3. compromising Tip60 histone acetyltransferase activity in the CySC lineage recapitulates loss-of-function phenotypes of E(Pc), suggesting that Tip60 and E(Pc) act together, consistent with published biochemical data. PMID: 28196077
4. critical for morphology and function of the mushroom body PMID: 26327426
5. Heat Shock Factor recruits the dTip60 complex to the hsp70 loci in cells treated with salicylate, which triggers chromatin remodeling at these loci without transcription activation. PMID: 24639513
6. Excess Tip60 exerts a neuroprotective role in axonal transport and functional locomotion defects in an animal model of Alzheimer's disease. PMID: 23616558
7. a novel mechanism for Tip60 mediated sleep-wake regulation via control of axonal growth and PDF levels within the small ventrolateral neurons-encompassing neural network PMID: 22982579
8. a functional interaction between Tip60 and APP in mediating nervous system development and apoptotic neuronal cell death PMID: 22848598
9. The role of Tip60 HAT activity in transcriptional control during multicellular development in vivo, was investigated. PMID: 21494552
10. Ubiquitous dTip60 knock-down in flies was lethal, whereas knock-down in the wing imaginal disk led to developmental defects. PMID: 19949809
11. demonstrated that the dTip60 chromatin-remodeling complex acetylates nucleosomal phospho-H2Av and exchanges it with an unmodified H2Av; both the histone acetyltransferase dTip60 and the atpase Domino/p400 catalyze the exchange of phospho-H2Av PMID: 15528408
12. TIP60 complex can promote the generation of silent chromatin. PMID: 16816423
13. TIP60 is differentially expressed during Drosophila development, with transcript levels significantly peaking during embryogenesis, and is essential for multicellular development. PMID: 17179074

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KEGG: dme:Dmel_CG6121

STRING: 7227.FBpp0070636

UniGene: Dm.75