tipE Antibody

Code CSB-PA344539XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) tipE Polyclonal antibody
Uniprot No.
Target Names
tipE
Alternative Names
tipE antibody; CG1232 antibody; Protein tipE antibody; Temperature-induced paralytic E antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) tipE protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Enhances para sodium channel function. Required during pupal development to rescue adult paralysis and also protects adult flies against heat-induced lethality.
Gene References into Functions
  1. TipE is a sodium channel gating protein that causes a hyperpolarizing shift in the voltage-dependence of fast inactivation of DmNav26. PMID: 23874427
  2. tipE regulates Na+-dependent repetitive firing in Drosophila neurons. PMID: 11906212
Subcellular Location
Membrane; Multi-pass membrane protein.
Tissue Specificity
Preferentially expressed in the central nervous system of developing embryos, weaker expression is seen in the peripheral nervous system. In pupae and adults, expression is seen predominantly in heads, body and legs.
Database Links

KEGG: dme:Dmel_CG1232

STRING: 7227.FBpp0073076

UniGene: Dm.6590

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