tmc-1 Antibody

Code CSB-PA586783XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans tmc-1 Polyclonal antibody
Uniprot No.
Target Names
tmc-1
Alternative Names
tmc-1 antibody; T13G4.3 antibody; Transmembrane channel-like protein 1 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans tmc-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Sodium-sensor ion channel that acts specifically in salt taste chemosensation. Required for salt-evoked neuronal activity and behavioral avoidance of high concentrations of NaCl.
Gene References into Functions
  1. Ectopic expression of TMC-1 confers alkaline sensitivity to alkali-insensitive cells PMID: 27321925
  2. TMC-1 has a role in regulating C. elegans development and sexual behaviour in a chemically defined food environment PMID: 25695879
  3. TMC-1 is both necessary for salt sensation in vivo and sufficient to generate a sodium-sensitive channel in vitro, identifying it as a probable ionotropic sensory receptor PMID: 23364694
Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
TMC family
Tissue Specificity
Expressed in the ASH polymodal avoidance neurons. Also expressed in other sensory neurons, including the ADF, ASE, ADL, AQR, PQR, URX and PHA cells.
Database Links

KEGG: cel:CELE_T13G4.3

STRING: 6239.T13G4.3

UniGene: Cel.364

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