toca-1 Antibody

Code CSB-PA996403XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans toca-1 Polyclonal antibody
Uniprot No.
Target Names
toca-1
Alternative Names
toca-1 antibody; F09E10.8 antibody; Transducer of Cdc42-dependent actin assembly protein 1 homolog antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans toca-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Plays a role in protein trafficking, actin organization and embryonic morphogenesis. Potentially acts as cdc-42 effector. May play a role in hypodermal P-cell nuclear positioning. Together with toca-2, is required for protein trafficking regulating yolk protein clathrin-mediated endocytosis by oocytes during oogenesis and retrograde recycling and the sorting of recycling endosome cargo proteins such as mig-14. Also, together with toca-2, controls the distribution of actin at cell junctions.
Gene References into Functions
  1. toca-1 is in a novel pathway that functions in parallel with a SUN-KASH nuclear envelope bridge to move nuclei in Caenorhabditis elegans. PMID: 23150597
Subcellular Location
Cell junction. Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Basolateral cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Cytoplasm. Cytoplasm, perinuclear region. Recycling endosome.
Protein Families
FNBP1 family
Tissue Specificity
Expressed in the germline and specifically in the gonads.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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