tolA Antibody

Datasheet

Code	CSB-PA321747XA01ENV
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Product Details

Full Product Name

Rabbit anti-Escherichia coli (strain K12) tolA Polyclonal antibody

Uniprot No.

P19934

Target Names

tolA

Alternative Names

tolA antibody; cim antibody; excC antibody; lky antibody; b0739 antibody; JW0729 antibody; Tol-Pal system protein TolA antibody

Raised in

Rabbit

Species Reactivity

Escherichia coli (strain K12)

Immunogen

Recombinant Escherichia coli (strain K12) tolA protein

Immunogen Species

Escherichia coli (strain K12)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Customer Reviews and Q&A

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Target Background

Function

Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. The Tol-Pal system is also required for polar localization of chemoreceptors clusters. The system also appears to be required for the activity of several outer membrane-localized enzymes with cell wall remodeling activity. Is involved in the uptake of group A colicins (colicins A, E1, E2, E3, and K) and in the uptake of filamentous phage DNA.

Gene References into Functions

Despite elevated virulence gene transcription, in tolA deleted strains virulence of enterohemorrhagic Escherichia coli in the Galleria mellonella wax worm model was substantially attenuated. PMID: 25448467
Variation of intragenic tandem repeat tract of tolA modulates Escherichia coli stress tolerance. PMID: 23094082
The authors show that the stable YbgF trimer undergoes a marked change in oligomeric state on binding TolA, forming a one-to-one complex with the Tol protein. PMID: 20816983
3D structure of free TolAIII by heteronuclear NMR spectroscopy PMID: 15701516
in vivo and in vitro coprecipitation analyses demonstrated that colicin A and g3p N-terminal domains compete for binding to TolA. PMID: 16237036
The Y. enterocolitica TolA supported the physiological function of the Tol system in E. coli, and conferred sensitivity to the TolA-dependent colicins. PMID: 18355278
energy transduced from the cytoplasmic membrane to the outer membrane by TolA could be the driving force for immunity protein release and concomitant translocation of the nuclease domain PMID: 19458090

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Subcellular Location

Cell inner membrane; Single-pass membrane protein.

Protein Families

TolA family

Database Links

KEGG: ecj:JW0729

STRING: 316385.ECDH10B_0806

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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tolA Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background