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TOR Antibody

Rare Species
Datasheet
Code CSB-PA861872XA01DOA
Size US$299
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Product Details

Full Product Name
Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) TOR Polyclonal antibody
Uniprot No.
Q9FR53
Target Names
TOR
Alternative Names
Serine/threonine-protein kinase TOR (EC 2.7.11.1) (Protein TARGET OF RAPAMYCIN) (AtTOR) TOR At1g50030 F2J10.19
Raised in
Rabbit
Species Reactivity
Arabidopsis thaliana
Immunogen
Recombinant Arabidopsis thaliana TOR protein (40-59aa)
Immunogen Species
Arabidopsis thaliana (Mouse-ear cress)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Essential cell growth regulator that controls development from early embryo to seed production. Controls plant growth in environmental stress conditions. Acts through the phosphorylation of downstream effectors that are recruited by the binding partner RAPTOR. Acts by activating transcription, protein synthesis and ribosome biogenesis, and inhibiting mRNA degradation and autophagy. Can phosphorylate TAP46, a regulatory subunit of protein phosphatase 2A that modulates cell growth and survival. Involved in modulating the transition from heterotrophic to photoautotrophic growth by regulating the expression of chloroplast- and photosynthesis-associated genes. Essential for auxin signaling transduction, probably acting in polysomes to maintain the active ATPK1/S6K1 (and thus TIF3H1/eIF3h) phosphorylation status that is critical for translation reinitiation (e.g. uORF-mRNAs loading). Promotes abscisic acid (ABA) biosynthesis. Involved in the regulation of sugar-mediated (e.g. glucose and sucrose) glycolysis- and mitochondrial bioenergetics-dependent root growth promotion. Required for sugar (e.g. glucose) promotion of hypocotyl elongation in the dark, by activating the brassinosteroid pathway and stabilizing BZR1. The regulation of BZR1 degradation is dependent on autophagy. Regulates the expression, phosphorylation and ribosome association of MRFs (e.g. MRF1, MRF3 and MRF4), especially under energy-deficient conditions.; (Microbial infection) Binding to cauliflower mosaic virus (CaMV) Tav protein is critical for both translation reinitiation and viral fitness. When activated by CaMV P6, promotes CaMV translation by inhibiting cellular autophagy and suppressing both silencing and innate immunity, thus confering sensitivity to P.syringae.; (Microbial infection) Required during infection by some potyvirus such as Watermelon mosaic virus (WMV) but not for turnip mosaic virus (TuMV).
Gene References into Functions
  1. Sugar-activated TOR kinase phosphorylates and stabilizes E2Fa proteins to transcriptionally activate S-phase genes during callus formation. PMID: 28623850
  2. The dependence of potyviruses on active Arabidopsis TOR signalling was different. PMID: 25979731
  3. These findings advance the current understanding of rapamycin-TOR signaling in plants. PMID: 23989449
  4. highlight the possible role of TOR in carbon utilization and growth regulation in Arabidopsis PMID: 23761348
  5. TOR protein regulates growth and also influences nutrient partitioning and central energy metabolism. PMID: 23173928
  6. systems, cellular and genetic analyses uncover TOR phosphorylation of E2Fa transcription factor for an unconventional activation of S-phase genes, and glucose-signalling defects in e2fa root meristems PMID: 23542588
  7. Rapamycin and glucose-target of rapamycin (TOR) protein signaling in plants. PMID: 22134914
  8. The authors show that the function of Cauliflower mosaic virus viroplasmin in reinitiation depends on physical association with TOR, with viroplasmin-TOR binding being critical for both translation reinitiation and viral fitness. PMID: 21343906
  9. TOR controls the embryogenesis, postembryonic development, and 45S rRNA production through its kinase domain in Arabidopsis. PMID: 21266656
  10. Results provide evidence that TOR is a negative regulator of autophagy in plants. PMID: 20686696
  11. The production of rapamycin-sensitive plants through the expression of baker's yeast FKBP12 protein illustrates the conservation of the TOR pathway in Arabidopsis. PMID: 17543119
  12. The AtTOR kinase is one of the contributors to the link between environmental cues and growth processes in plants. PMID: 17721444

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Subcellular Location
Cytoplasm. Nucleus.
Protein Families
PI3/PI4-kinase family
Tissue Specificity
Highly expressed in root meristems, shoot apical meristem (SAM) and floral buds.
Database Links

KEGG: ath:AT1G50030

STRING: 3702.AT1G50030.1

UniGene: At.16944

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