tor1 Antibody

Code CSB-PA521136XA01SXV
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Product Details

Full Product Name
Rabbit anti-Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) tor1 Polyclonal antibody
Uniprot No.
Target Names
tor1
Alternative Names
tor1 antibody; SPBC30D10.10c antibody; Serine/threonine-protein kinase tor1 antibody; EC 2.7.11.1 antibody; Phosphatidylinositol kinase homolog tor1 antibody; Target of rapamycin kinase 1 antibody
Raised in
Rabbit
Species Reactivity
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Immunogen
Recombinant Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) tor1 protein
Immunogen Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Phosphatidylinositol 3-kinase homolog, component of TORC2, which regulates multiple cellular processes to control cell growth in response to environmental signals. TORC2 is required for cell survival under various stress conditions. TORC2 positively controls G1 cell-cycle arrest, sexual development and amino acid uptake. Positively regulates amino acid uptake through the control of expression of amino acid permeases. Responsible for the phosphorylation of AGC kinase gad8 at 'Ser-527' and 'Ser-546', activating gad8 kinase activity and promoting sexual development.
Gene References into Functions
  1. While mutated TORC1 and TORC2 displayed diminished kinase activity and FKBP12/Fkh1-dependent rapamycin sensitivity, their phenotypes were nearly opposite in mitosis. PMID: 22645648
  2. Tor1 and the Tsc1-2 complex work in parallel positively regulating amino acid uptake through the control of expression of amino acid permeases, and either one is required for growth on a poor nitrogen source. PMID: 17179073
  3. Results suggest that S. pombe Tor1 and Tor2 can both act in TORC1, but it is the inhibition of Tor1 as part of TORC1 that promotes mitosis following nutrient stress. PMID: 19417002
  4. Data highlight critical roles for TORC2 and its component Tor1 in chromatin metabolism and in promoting mitotic entry, most notably after recovery from DNA-damaging conditions. PMID: 19546237
Subcellular Location
Cytoplasm.
Protein Families
PI3/PI4-kinase family
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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