tor Antibody

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Code	CSB-PA323590XA01DLU
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Target Background

Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) tor Polyclonal antibody

Uniprot No.

P18475

Target Names

tor

Alternative Names

tor antibody; CG1389 antibody; Tyrosine-protein kinase receptor torso antibody; EC 2.7.10.1 antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) tor protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Probable receptor tyrosine kinase which is required for determination of anterior and posterior terminal structures in the embryo. During postembryonic development, involved in the initiation of metamorphosis probably by inducing the production of ecdysone in response to prothoracicotropic hormone Ptth. Binding to Ptth stimulates activation of canonical MAPK signaling leading to ERK phosphorylation.

Gene References into Functions

Cic functions are independent of RTK regulation and may depend on cofactor-assisted DNA binding. PMID: 29432195
Mechanistically, the authors identify foxo and mTOR homologue, Tor as important regulators of germline stem cells quiescence following exposure to ionizing radiation. foxo is required for entry in quiescence, while Tor is essential for cell cycle reentry. PMID: 28925355
Our study revealed a novel role for Torso in the fat body with respect to regulation of insulin/TOR signaling and body size. PMID: 27126913
Data suggest that Tor signaling governs Yki (Yorkie protein) action after reaching nucleus by allowing access to target genes via Hpo (Hippo protein) pathway; Tor also promotes wing growth by liberating Yki from nuclear seclusion. PMID: 26474042
The conserved Tor metabolic sensing pathway regulates yolk catabolism. PMID: 26395483
down-regulates Capicua at the embryonic termini PMID: 20404518
Data indicate that Torso-like (Tsl) and receptor tyrosine kinase Torso (Tor) have opposing effects on body size. PMID: 23959885
repeated Torso activation is linked to a duplication and differential expression of a ligand-encoding gene, the acquisition of distinct enhancers in the torso-like promoter and the recruitment of proteins independently required for embryogenesis PMID: 23094137
Torso reduces the stability of Capicua by controlling the rates of its nucleocytoplasmic transport PMID: 23048183
The Torso RTK is required for proper migration of primordial germ cells in Drosophila. PMID: 21618099
characterized a new psq loss-of-function allele, psq(rum), which specifically affects signaling by the Torso (Tor) receptor tyrosine kinase (RTK) PMID: 21098720
closca is a gene encoding a new member of a group of proteins that act non-redundantly in vitelline membrane biogenesis and in Torso signalling; Nasrat protein is another member of this group incorporated into the vitelline membrane PMID: 20457146
During embryogenesis, the activated Torso receptor tyrosine kinase (TOR RTK) pathway activates tailless (tll) expression by a relief-of-repression mechanism. PMID: 12128207
STAT, encoded by marelle (mrl; DStat92E), is essential for the gain-of-function mutant Tor (Tor(GOF)) to activate ectopic gene expression PMID: 12183376
Data show that in Drosophila, the receptor tyrosine kinase Torso activates both STAT92E and Ras1 during the early phase of primordial germ cell development. PMID: 14602078
the Torso RTK pathway has a role in downregulation of Capicua repression and tailless activation in the Drosophila embryo PMID: 16753285
A specific feature of Torso pathway signaling is the fact that the cell-cell contact at the origin of the triggering mechanism is established much earlier than the signaling mechanism itself. PMID: 17595301
lack of pgc partly ameliorates the cellularization defect of tor mutants, thus revealing a functional antagonism between pgc and tor in the specification of germline and somatic properties. PMID: 19644502

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Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Families

Protein kinase superfamily, Tyr protein kinase family

Database Links

KEGG: dme:Dmel_CG1389

STRING: 7227.FBpp0111751

UniGene: Dm.512

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