TRAPPC12 Antibody

Code CSB-PA855484XA01HU
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TRAPPC12 Polyclonal antibody
Uniprot No.
Target Names
TRAPPC12
Alternative Names
CGI 87 antibody; CGI87 antibody; DKFZp547E107 antibody; FLJ36862 antibody; Tetratricopeptide repeat domain 15 antibody; Tetratricopeptide repeat protein 15 antibody; TPR repeat protein 15 antibody; Trafficking protein particle complex 12 antibody; Trafficking protein particle complex subunit 12 antibody; TRAPPC12 antibody; TTC 15 antibody; TTC15 antibody; TTC15_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Homo sapiens (Human)
Immunogen
Recombinant Homo sapiens (Human) TRAPPC12 protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Component of the TRAPP complex, which is involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage. Also plays a role in chromosome congression, kinetochore assembly and stability and controls the recruitment of CENPE to the kinetochores.
Gene References into Functions
  1. TRAPPC12, but not TRAPPC8, bound to Sec13/Sec31A tetramer but each Sec protein alone could not interact with TRAPPC12. PMID: 28240221
  2. The authors report that variants in TRAPPC12 result in progressive childhood encephalopathy. Fibroblasts derived from three affected individuals showed a fragmented Golgi that could be rescued by expression of wild-type TRAPPC12. PMID: 28777934
Subcellular Location
Endoplasmic reticulum-Golgi intermediate compartment. Nucleus.
Database Links

HGNC: 24284

OMIM: 614139

KEGG: hsa:51112

STRING: 9606.ENSP00000324318

UniGene: Hs.252713

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