tra-1 Antibody

Code CSB-PA624161XA01CXX
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis briggsae tra-1 Polyclonal antibody
Uniprot No.
Target Names
tra-1
Alternative Names
tra-1 antibody; CBG13188 antibody; Sex-determining transformer protein 1 antibody; Cbr-tra-1 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis briggsae
Immunogen
Recombinant Caenorhabditis briggsae tra-1 protein
Immunogen Species
Caenorhabditis briggsae
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Plays a major role in controlling sexual phenotype. Terminal global regulator in a well-characterized cascade of sex-determining genes. Promotes female development. Interacts with tra-2 to promote spermatogenesis. Promotes spermatogenesis through the Tip60 HAT complex and by regulating the expression of genes, such as fog-3, required for male development. Association with chromatin and at the fog-3 promoter requires wdr-5.1, and may also require wdr-5.2. With trr-1, activates the fog-3 gene to determine sperm/oocyte cell fate. In hermaphrodites, binds to an intronic regulatory site in the ceh-30 gene, preventing ceh-30 transcription and thereby preventing survival of the CEM (cephalic male) sensory neurons. Represses the expression of the transcription factor dmd-3 in hermaphrodites to govern the timing and extent of male tail tip morphogenesis. Plays a role in controlling the sex-specific differentiation of PHC sensory neurons and represses the development of male-specific morphological features.
Subcellular Location
Nucleus. Cytoplasm.
Protein Families
GLI C2H2-type zinc-finger protein family
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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