TRAIP Antibody

Datasheet
Code CSB-PA866296ZA01HU
Uniprot No. Q9BWF2
Delivery Make-to-order
Protocols ELISA Protocol
Immunogen Recombinant Human E3 ubiquitin-protein ligase TRAIP (TRAIP) (1-469AA)
Raised in Rabbit
Species Reactivity Homo sapiens
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugate
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias E3 ubiquitin-protein ligase TRAIP (EC 2.3.2.27) (RING finger protein 206) (RING-type E3 ubiquitin transferase TRAIP) (TRAF-interacting protein), TRAIP, RNF206 TRIP
Immunogen Species Homo sapiens (Human)
Gene Names TRAIP
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function E3 ubiquitin ligase acting as a negative regulator of innate immune signaling. Inhibits activation of NF-kappa-B mediated by TNF. Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation (By similarity)
Involvement in disease Seckel syndrome 9 (SCKL9)
Subcellular Location Cytoplasm, Cytoplasm, perinuclear region, Nucleus, Nucleus, nucleolus
Database Links

HGNC: 30764

OMIM: 605958

KEGG: hsa:10293

STRING: 9606.ENSP00000328203

UniGene: Hs.517972

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