TRAIP Antibody

Datasheet
Code CSB-PA697715
Size US$299
Uniprot No. Q9BWF2
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA697715(TRAIP Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA697715(TRAIP Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Fusion protein of Human TRAIP
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA,IHC;ELISA:1:2000-1:10000,IHC:1:30-1:150
Relevance This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis.
Form Liquid
Conjugate Non-conjugated
Storage Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method Antigen affinity purification
Isotype IgG
Alias TRAF interacting protein
Immunogen Species Homo sapiens (Human)
Target Names TRAIP
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function E3 ubiquitin ligase acting as a negative regulator of innate immune signaling. Inhibits activation of NF-kappa-B mediated by TNF. Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation (By similarity)
Involvement in disease Seckel syndrome 9 (SCKL9)
Subcellular Location Cytoplasm, Cytoplasm, perinuclear region, Nucleus, Nucleus, nucleolus
Database Links

HGNC: 30764

OMIM: 605958

KEGG: hsa:10293

STRING: 9606.ENSP00000328203

UniGene: Hs.517972

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