trpa-1 Antibody

Code CSB-PA613821XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans trpa-1 Polyclonal antibody
Uniprot No.
Target Names
trpa-1
Alternative Names
trpa-1 antibody; C29E6.2 antibody; Transient receptor potential cation channel subfamily A member 1 homolog antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans trpa-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Receptor-activated non-selective cation channel involved in the nose-touch response and foraging behavior. Contributes to the neural responses of sensory neurons to touch, particularly after repeated mechanical stimulation. Has no apparent role in thermosensory or chemosensory behaviors.
Gene References into Functions
  1. Study reveals that TRPA-1, a cold-sensitive TRP channel, detects temperature drop in the environment to extend lifespan. This effect requires cold-induced, TRPA-1-mediated calcium influx and a calcium-sensitive PKC that signals to the transcription factor DAF-16/FOXO. PMID: 23415228
  2. harsh touch specifically required the DEG/ENaC proteins MEC-10 and DEGT-1 (F25D1.4), which represent putative components of a harsh touch mechanotransduction complex; responses to cold required the TRPA-1 channel and were MEC-10 and DEGT-1 independent PMID: 20512132
  3. This study demonstrates that trpa-1 encodes an ion channel that can be activated in response to mechanical pressure and is required for mechanosensory neuron function. PMID: 17450139
Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
Transient receptor (TC 1.A.4) family
Tissue Specificity
Expressed in many sensory neurons, including OLQ and IL1 neurons.
Database Links

KEGG: cel:CELE_C29E6.2

STRING: 6239.C29E6.2

UniGene: Cel.5648

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